ID   PAHX_DICDI              Reviewed;         349 AA.
AC   P0DPA0; Q54J59;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Putative phytanoyl-CoA dioxygenase {ECO:0000250|UniProtKB:O14832};
DE            EC=1.14.11.18 {ECO:0000250|UniProtKB:O14832};
DE   AltName: Full=Phytanic acid oxidase {ECO:0000250|UniProtKB:O14832};
DE   AltName: Full=Phytanoyl-CoA alpha-hydroxylase {ECO:0000250|UniProtKB:O14832};
DE            Short=PhyH {ECO:0000250|UniProtKB:O14832};
GN   ORFNames=DDB_G0349042;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
CC       {ECO:0000250|UniProtKB:O14832}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA +
CC         CO2 + succinate; Xref=Rhea:RHEA:16065, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:57334, ChEBI:CHEBI:57391; EC=1.14.11.18;
CC         Evidence={ECO:0000250|UniProtKB:O14832};
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000250|UniProtKB:O14832};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC         Evidence={ECO:0000250|UniProtKB:O14832};
CC   -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC       {ECO:0000250|UniProtKB:O14832}.
CC   -!- SIMILARITY: Belongs to the PhyH family. {ECO:0000305}.
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DR   EMBL; AAFI02000169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DPA0; -.
DR   dictyBase; DDB_G0349042; -.
DR   UniPathway; UPA00199; -.
DR   PRO; PR:P0DPA0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048244; F:phytanoyl-CoA dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR008775; Phytyl_CoA_dOase.
DR   Pfam; PF05721; PhyH; 1.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..349
FT                   /note="Putative phytanoyl-CoA dioxygenase"
FT                   /id="PRO_0000442005"
FT   BINDING         118
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         169..171
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         169
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         171
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
SQ   SEQUENCE   349 AA;  40645 MW;  56626C1A769E7EC4 CRC64;
     MEEILKSFKI SIDNEGYSKS FSLEDLDNFN NNNNNNNNNN NNEENNPYEF FERYGFLVIR
     NVISEEDCNK TVGEIFDIIE SKVKTFDRND QSTWDQTFSE DGSSIPQYGS PSKPPIFKKQ
     FLMNRTNPNV YKVFSKLLKN QDLMVNHDRA CFFRPTLVNP KWKTNDNVHL DMNPYNWMGN
     GDICREELSK LTYARLGEFI VENNQPTQND GLQLQGVINL LDNQELDGGY CVTPGFHTIF
     NEYFTSKKPQ YTSPSWNFDK KDIAFKYAKR ISMRKGSIVV WNQQMPHGSM SNKSFNPRMA
     QFIKIFPTST VNSVRYQHRK NQIKSIIENS DELKDFPLNQ ISSQLLGLN