PAI2B_HUMAN
ID PAI2B_HUMAN Reviewed; 123 AA.
AC Q9ULR5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Polyadenylate-binding protein-interacting protein 2B;
DE Short=PABP-interacting protein 2B;
DE Short=PAIP-2B;
DE Short=Poly(A)-binding protein-interacting protein 2B;
GN Name=PAIP2B; Synonyms=KIAA1155;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [2]
RP FUNCTION, INTERACTION WITH PABPC1, TISSUE SPECIFICITY, AND UBIQUITINATION.
RX PubMed=16804161; DOI=10.1261/rna.106506;
RA Berlanga J.J., Baass A., Sonenberg N.;
RT "Regulation of poly(A) binding protein function in translation:
RT Characterization of the Paip2 homolog, Paip2B.";
RL RNA 12:1556-1568(2006).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: Inhibits translation of capped and polyadenylated mRNAs by
CC displacing PABPC1 from the poly(A) tail. {ECO:0000269|PubMed:16804161}.
CC -!- SUBUNIT: Interacts (via central acidic portion and C-terminus) with
CC PABPC1 (via the second and third RRM domains and the C-terminus).
CC {ECO:0000269|PubMed:16804161}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, cervix, heart, liver, ovary,
CC kidney, prostate and testis. {ECO:0000269|PubMed:16804161}.
CC -!- PTM: Ubiquitinated in vitro. {ECO:0000269|PubMed:16804161}.
CC -!- SIMILARITY: Belongs to the PAIP2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86469.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB032981; BAA86469.1; ALT_INIT; mRNA.
DR CCDS; CCDS46322.1; -.
DR RefSeq; NP_065192.1; NM_020459.1.
DR RefSeq; XP_005264367.1; XM_005264310.3.
DR RefSeq; XP_005264368.1; XM_005264311.4.
DR RefSeq; XP_011531145.1; XM_011532843.2.
DR AlphaFoldDB; Q9ULR5; -.
DR BioGRID; 134843; 193.
DR ELM; Q9ULR5; -.
DR IntAct; Q9ULR5; 9.
DR STRING; 9606.ENSP00000244221; -.
DR iPTMnet; Q9ULR5; -.
DR PhosphoSitePlus; Q9ULR5; -.
DR BioMuta; PAIP2B; -.
DR DMDM; 166977703; -.
DR EPD; Q9ULR5; -.
DR MassIVE; Q9ULR5; -.
DR MaxQB; Q9ULR5; -.
DR PaxDb; Q9ULR5; -.
DR PeptideAtlas; Q9ULR5; -.
DR PRIDE; Q9ULR5; -.
DR ProteomicsDB; 85101; -.
DR Antibodypedia; 56903; 14 antibodies from 9 providers.
DR DNASU; 400961; -.
DR Ensembl; ENST00000244221.9; ENSP00000244221.8; ENSG00000124374.9.
DR GeneID; 400961; -.
DR KEGG; hsa:400961; -.
DR MANE-Select; ENST00000244221.9; ENSP00000244221.8; NM_020459.1; NP_065192.1.
DR UCSC; uc002shu.3; human.
DR CTD; 400961; -.
DR DisGeNET; 400961; -.
DR GeneCards; PAIP2B; -.
DR HGNC; HGNC:29200; PAIP2B.
DR HPA; ENSG00000124374; Tissue enhanced (brain, choroid plexus).
DR MIM; 611018; gene.
DR neXtProt; NX_Q9ULR5; -.
DR OpenTargets; ENSG00000124374; -.
DR PharmGKB; PA162398595; -.
DR VEuPathDB; HostDB:ENSG00000124374; -.
DR eggNOG; ENOG502S63Z; Eukaryota.
DR GeneTree; ENSGT00390000017284; -.
DR HOGENOM; CLU_134152_0_0_1; -.
DR InParanoid; Q9ULR5; -.
DR OMA; QGLNGHE; -.
DR OrthoDB; 1624094at2759; -.
DR PhylomeDB; Q9ULR5; -.
DR TreeFam; TF326855; -.
DR PathwayCommons; Q9ULR5; -.
DR SignaLink; Q9ULR5; -.
DR BioGRID-ORCS; 400961; 5 hits in 1065 CRISPR screens.
DR ChiTaRS; PAIP2B; human.
DR GenomeRNAi; 400961; -.
DR Pharos; Q9ULR5; Tbio.
DR PRO; PR:Q9ULR5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9ULR5; protein.
DR Bgee; ENSG00000124374; Expressed in corpus callosum and 198 other tissues.
DR Genevisible; Q9ULR5; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IDA:HGNC-UCL.
DR GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR GO; GO:0045947; P:negative regulation of translational initiation; IDA:HGNC-UCL.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR040396; PAIP2-like.
DR PANTHER; PTHR13154; PTHR13154; 1.
DR Pfam; PF07145; PAM2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome; Repressor; Translation regulation;
KW Ubl conjugation.
FT CHAIN 1..123
FT /note="Polyadenylate-binding protein-interacting protein
FT 2B"
FT /id="PRO_0000317294"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330"
SQ SEQUENCE 123 AA; 14237 MW; D1C85F950BD651C3 CRC64;
MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE LQEQDFLDRC
FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD SEDILSKSNL NPDAKEFIPG
EKY
