ID   PAIB_BACSU              Reviewed;         207 AA.
AC   P21341; O05270;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 3.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protease synthase and sporulation protein PAI 2;
GN   Name=paiB; Synonyms=yumE; OrderedLocusNames=BSU32140;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-5.
RC   STRAIN=168 / DB104;
RX   PubMed=2108124; DOI=10.1128/jb.172.4.1783-1790.1990;
RA   Honjo M., Nakayama A., Fukazawa K., Kawamura K., Ando K., Hori M.,
RA   Furutani Y.;
RT   "A novel Bacillus subtilis gene involved in negative control of sporulation
RT   and degradative-enzyme production.";
RL   J. Bacteriol. 172:1783-1790(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 126-134.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-207.
RC   STRAIN=168;
RA   Oudega B., Koningstein G., de Sales Ramon M., Rodrigues L.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the reduction of extracellular and cell-
CC       associated protease levels, as well as in the reduced levels of alpha-
CC       amylase, levansucrase, alkaline phosphatase and sporulation inhibition,
CC       when present in high copy number.
CC   -!- SIMILARITY: Belongs to the PaiB family. {ECO:0000305}.
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DR   EMBL; M36471; AAA22639.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15204.2; -; Genomic_DNA.
DR   EMBL; Z93939; CAB07956.1; -; Genomic_DNA.
DR   PIR; B35145; B35145.
DR   PIR; F69671; F69671.
DR   RefSeq; NP_391094.2; NC_000964.3.
DR   RefSeq; WP_003244329.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P21341; -.
DR   SMR; P21341; -.
DR   STRING; 224308.BSU32140; -.
DR   PaxDb; P21341; -.
DR   PRIDE; P21341; -.
DR   EnsemblBacteria; CAB15204; CAB15204; BSU_32140.
DR   GeneID; 936588; -.
DR   KEGG; bsu:BSU32140; -.
DR   PATRIC; fig|224308.179.peg.3480; -.
DR   eggNOG; COG2808; Bacteria.
DR   InParanoid; P21341; -.
DR   OMA; ARANPQW; -.
DR   PhylomeDB; P21341; -.
DR   BioCyc; BSUB:BSU32140-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   InterPro; IPR007396; TR_PAI2-type.
DR   PANTHER; PTHR35802; PTHR35802; 1.
DR   Pfam; PF04299; FMN_bind_2; 1.
DR   PIRSF; PIRSF010372; PaiB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Sporulation.
FT   CHAIN           1..207
FT                   /note="Protease synthase and sporulation protein PAI 2"
FT                   /id="PRO_0000058176"
FT   CONFLICT        126..134
FT                   /note="KYEKHRDNP -> QKTPTQAFS (in Ref. 4; CAB07956)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  24284 MW;  A0C5425B9B97D93D CRC64;
     MYIPKYFKVT NAEEIWNFVQ ENSFGTVVTT EQGKPIATHL PLGFNKKDDH YYITGHFAYG
     NPQWRTFEAC EDVLVMFQGP HAYISSSWYS RENVPTWNYQ AVHMYGKASM LEKDELAEEL
     TIMLEKYEKH RDNPVLWDKL SPKLLESELK GIVGFKIKVE DIQAAYKLSQ NRNETDYMNV
     IEQLQNEENP NAKQMAELME DKLKKQI