ID   PAIP2_PONAB             Reviewed;         124 AA.
AC   Q5R596;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Polyadenylate-binding protein-interacting protein 2;
DE            Short=PABP-interacting protein 2;
DE            Short=PAIP-2;
DE            Short=Poly(A)-binding protein-interacting protein 2;
GN   Name=PAIP2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a repressor in the regulation of translation
CC       initiation of poly(A)-containing mRNAs. Its inhibitory activity on
CC       translation is mediated via its action on PABPC1. Displaces the
CC       interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for
CC       binding to PABPC1. Its association with PABPC1 results in disruption of
CC       the cytoplasmic poly(A) RNP structure organization (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the second and third RRM domains and C-terminus
CC       regions of PABPC1 in a 2:1 stoichiometry. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Only the PABPC1-interacting motif-1 (PAM1) interferes with the
CC       binding of PABPC1 to poly(A) RNA and translation initiation.
CC       {ECO:0000250}.
CC   -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC       {ECO:0000250|UniProtKB:Q9BPZ3}.
CC   -!- SIMILARITY: Belongs to the PAIP2 family. {ECO:0000305}.
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DR   EMBL; CR860968; CAH93070.1; -; mRNA.
DR   RefSeq; NP_001126818.1; NM_001133346.1.
DR   AlphaFoldDB; Q5R596; -.
DR   BMRB; Q5R596; -.
DR   STRING; 9601.ENSPPYP00000017707; -.
DR   GeneID; 100173823; -.
DR   KEGG; pon:100173823; -.
DR   CTD; 51247; -.
DR   eggNOG; ENOG502RZKX; Eukaryota.
DR   InParanoid; Q5R596; -.
DR   OrthoDB; 1624094at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR   InterPro; IPR009818; Ataxin-2_C.
DR   InterPro; IPR040396; PAIP2-like.
DR   PANTHER; PTHR13154; PTHR13154; 1.
DR   Pfam; PF07145; PAM2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Translation regulation; Ubl conjugation.
FT   CHAIN           1..124
FT                   /note="Polyadenylate-binding protein-interacting protein 2"
FT                   /id="PRO_0000252687"
FT   REGION          22..75
FT                   /note="PABPC1-interacting motif-1 (PAM1)"
FT                   /evidence="ECO:0000250"
FT   REGION          105..120
FT                   /note="PABPC1-interacting motif-2 (PAM2)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  14744 MW;  8871AD3A22D62022 CRC64;
     MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC
     FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNELVISDSS SLEDLVVKSN LNPNAKEFVP
     GVKY