A32CD_DROME
ID A32CD_DROME Reviewed; 252 AA.
AC O46203; O46225; Q8T4D3; Q9TY45; Q9VKL2; X2J5M2;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 3.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Accessory gland protein Acp32CD;
DE Flags: Precursor;
GN Name=Acp32CD; ORFNames=CG4605;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 32-252, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF
RP 1-45, FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Male accessory gland;
RX PubMed=9474779; DOI=10.1016/s0965-1748(97)00056-8;
RA Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W.,
RA Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.;
RT "New genes for male accessory gland proteins in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 27:825-834(1997).
CC -!- FUNCTION: Responsible for physiological and behavioral changes in mated
CC female flies. {ECO:0000269|PubMed:9474779}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Seminal fluid. {ECO:0000269|PubMed:9474779}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB96388.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAB96389.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAB96395.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF53055.2; -; Genomic_DNA.
DR EMBL; AE014134; AHN54343.1; -; Genomic_DNA.
DR EMBL; AY089245; AAL89983.1; -; mRNA.
DR EMBL; U85764; AAB96388.1; ALT_SEQ; Genomic_DNA.
DR EMBL; U85764; AAB96389.1; ALT_SEQ; Genomic_DNA.
DR EMBL; U90948; AAB96395.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001285829.1; NM_001298900.1.
DR RefSeq; NP_477328.2; NM_057980.5.
DR AlphaFoldDB; O46203; -.
DR IntAct; O46203; 2.
DR STRING; 7227.FBpp0079747; -.
DR PaxDb; O46203; -.
DR DNASU; 34531; -.
DR EnsemblMetazoa; FBtr0080158; FBpp0079747; FBgn0023415.
DR EnsemblMetazoa; FBtr0344020; FBpp0310471; FBgn0023415.
DR GeneID; 34531; -.
DR KEGG; dme:Dmel_CG4605; -.
DR CTD; 34531; -.
DR FlyBase; FBgn0023415; Acp32CD.
DR VEuPathDB; VectorBase:FBgn0023415; -.
DR eggNOG; ENOG502RVRM; Eukaryota.
DR OMA; KYYMNFA; -.
DR OrthoDB; 1539696at2759; -.
DR BioGRID-ORCS; 34531; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34531; -.
DR PRO; PR:O46203; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0023415; Expressed in male reproductive gland and 8 other tissues.
DR ExpressionAtlas; O46203; baseline and differential.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; ISM:FlyBase.
DR GO; GO:0005179; F:hormone activity; NAS:UniProtKB.
DR GO; GO:0045434; P:negative regulation of female receptivity, post-mating; NAS:UniProtKB.
DR GO; GO:0019953; P:sexual reproduction; IEP:FlyBase.
PE 2: Evidence at transcript level;
KW Behavior; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..252
FT /note="Accessory gland protein Acp32CD"
FT /evidence="ECO:0000255"
FT /id="PRO_0000443083"
FT REGION 42..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 218
FT /note="N -> T (in Ref. 3; AAL89983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 25998 MW; 5F7615F1FE88D890 CRC64;
MWRMRMRLLT GYLVLLALGQ LPEHGALGQK YYMNFAFNNN NPDGEGGTGV DGGGGGAGGG
AAGPGGGTGD SPHSQEGDGS AATDNPNDDH ATSADNSLAT DGDAIGKKES GGGSDGKSDS
KDSSGGNDAT PANGHDDDND DSDSKDAKDR QDKEEEAGQE GKRTDHSHHS SYEISIDDSF
GGRYVRSIYE SSESHGHSGS NAGSNQRDNG ARESSQENQD AKEVASEAPA QRAGNVPDGP
ETGAKEDDYE EM
