PAL1_CAEBR
ID PAL1_CAEBR Reviewed; 271 AA.
AC A8XSQ8;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Homeobox protein pal-1 {ECO:0000250|UniProtKB:P34766};
DE AltName: Full=Posterior alae in males protein 1 {ECO:0000250|UniProtKB:P34766};
GN Name=pal-1 {ECO:0000312|EMBL:CAP35510.1}; ORFNames=CBG17980;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP35510.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Transcriptional activator. Interacts with promoter regions
CC for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the
CC sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene
CC promoter during embryonic body wall muscle development. Activates the
CC gene for mab-5 in embryo development. Necessary for vab-7 expression in
CC C blastomeres in the posterior of embryos. Required for posterior V6
CC neuroectoblast cell fate specification during postembryonic
CC neurogenesis (patterning) which generates the characteristic ray
CC lineage during male tail development. Binds to ced-3 promoter and
CC activated expression which is crucial for tail-spike cell death. Has a
CC role in E cell specification in endoderm development and body wall
CC muscle development (By similarity). {ECO:0000250|UniProtKB:P34766}.
CC -!- SUBUNIT: Interacts with tir-1 and let-756.
CC {ECO:0000250|UniProtKB:P34766}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P34766}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P34766}.
CC Chromosome. Note=Localized to condensed chromosomes.
CC {ECO:0000250|UniProtKB:P34766}.
CC -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000255}.
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DR EMBL; HE600963; CAP35510.1; -; Genomic_DNA.
DR RefSeq; XP_002642043.1; XM_002641997.1.
DR AlphaFoldDB; A8XSQ8; -.
DR SMR; A8XSQ8; -.
DR STRING; 6238.CBG17980; -.
DR GeneID; 8584037; -.
DR KEGG; cbr:CBG_17980; -.
DR CTD; 8584037; -.
DR WormBase; CBG17980; CBP41750; WBGene00037480; Cbr-pal-1.
DR eggNOG; KOG0848; Eukaryota.
DR HOGENOM; CLU_1031470_0_0_1; -.
DR InParanoid; A8XSQ8; -.
DR OMA; VWPFMDY; -.
DR OrthoDB; 1327315at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Activator; Centromere; Chromosome; Developmental protein; DNA-binding;
KW Homeobox; Kinetochore; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..271
FT /note="Homeobox protein pal-1"
FT /id="PRO_0000393938"
FT DNA_BIND 207..266
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 30296 MW; 79D970ECD37FF349 CRC64;
MSVDVKSEFS ENDSSSSSSS PTNVNNVAWP NYQMMPFMNA QPLRDKMLQP SFDPQLYGRW
PQMGEAGFYG HSDIYSTFAL PQLSTNGQIL PTAEVVEVKP PLSNGSSSSD SGMYPSPNDL
TPFPSTSSGI GASSSSSDLQ AAAAAAANYQ MRAATCYQQS VWPFMDYQQP FPWKMPLGSA
GKERRASSDT KSLPTGPGTN NVRVRTADKY RMVYSDYQRL ELEKEFHTSA FITSDRKSQL
STMLSLTERQ IKIWFQNRRA KDRRDKQKIR L
