PALA_CANAL
ID PALA_CANAL Reviewed; 785 AA.
AC Q9UW12; A0A1D8PEK4; Q5APG5;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=pH-response regulator protein palA/RIM20;
GN Name=RIM20; Synonyms=ENX3; OrderedLocusNames=CAALFM_C109380WA;
GN ORFNames=CaO19.12263, CaO19.4800;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SC5314 / CAI4 / ATCC MYA-682;
RX PubMed=10629054; DOI=10.1128/mcb.20.3.971-978.2000;
RA Davis D.A., Wilson R.B., Mitchell A.P.;
RT "RIM101-dependent and -independent pathways govern pH responses in Candida
RT albicans.";
RL Mol. Cell. Biol. 20:971-978(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH. May act as a scaffold
CC protein that recruits the calpain-like protease RIM13 via SNF7 to its
CC substrate RIM101 (By similarity). Required for filamentation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RIM101 by binding to its two YPX[LI] motifs.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palA/RIM20 family. {ECO:0000305}.
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DR EMBL; AF173843; AAD51716.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26572.1; -; Genomic_DNA.
DR RefSeq; XP_723486.1; XM_718393.2.
DR AlphaFoldDB; Q9UW12; -.
DR SMR; Q9UW12; -.
DR BioGRID; 1217903; 1.
DR IntAct; Q9UW12; 1.
DR STRING; 237561.Q9UW12; -.
DR GeneID; 3634809; -.
DR KEGG; cal:CAALFM_C109380WA; -.
DR CGD; CAL0000180949; RIM20.
DR VEuPathDB; FungiDB:C1_09380W_A; -.
DR eggNOG; KOG2220; Eukaryota.
DR HOGENOM; CLU_007181_2_1_1; -.
DR InParanoid; Q9UW12; -.
DR OrthoDB; 550620at2759; -.
DR PRO; PR:Q9UW12; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0071285; P:cellular response to lithium ion; IMP:CGD.
DR GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
DR GO; GO:0071467; P:cellular response to pH; IMP:CGD.
DR GO; GO:0044409; P:entry into host; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0036177; P:filamentous growth of a population of unicellular organisms in response to pH; IMP:CGD.
DR GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR Gene3D; 1.25.40.280; -; 1.
DR InterPro; IPR025304; ALIX_V_dom.
DR InterPro; IPR045251; BRO1-like.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR PANTHER; PTHR23030; PTHR23030; 1.
DR Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR Pfam; PF03097; BRO1; 1.
DR SMART; SM01041; BRO1; 1.
DR PROSITE; PS51180; BRO1; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..785
FT /note="pH-response regulator protein palA/RIM20"
FT /id="PRO_0000218875"
FT DOMAIN 4..403
FT /note="BRO1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT REGION 748..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 80
FT /note="T -> A (in Ref. 1; AAD51716)"
FT /evidence="ECO:0000305"
FT CONFLICT 124
FT /note="S -> T (in Ref. 1; AAD51716)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="S -> P (in Ref. 1; AAD51716)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="A -> T (in Ref. 1; AAD51716)"
FT /evidence="ECO:0000305"
FT CONFLICT 669
FT /note="L -> V (in Ref. 1; AAD51716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 90713 MW; 81EA1662AF6BDD25 CRC64;
MNTNLLFIPL KQSSVLDLGD ELRQVITNNY FQPASSFNSD LIYITQLRNQ VAQIKNVNDE
LGKTSQDDSI LLEYLQVLNT LQNKFSDDCV EFAWFDTLAY GPQGPYRYRS LKIEKLNVIY
QIGSLYSQIA ISESRHTDIG LKRACHYFQL SAGCFMFINN FLIETIKNKN DPLVLSIPLS
MQSSTIQCLE YLMLAQAQET IWQKAINNNS MKDSVVARLS IQTSEYYSKA LDFGNSSDLI
KLEWINHMKV KKLHFLAAAH LRSSTIAADS FQYGEQVAHL RVASQAVDQA LKSKKYVNSL
VLEDLQGLAD VIKVRLRTAE KDNDLVYLKI VPQEKELKTI IGVSMVKSII PEAFEQKPES
NTEIFKELLP YVIIHVAQAM RERQDEYVQT KFHTPISSLN NMLVKFLIDR DLPSSIDSIQ
QPENIPDSVI HHSQEILKTG GVDFIDKAFK ELDKLKLECN HLLQECETRI DLDRSEDDML
RRKQGSTRWT RKSTDDAAQE LIKKVDKMKQ YLLQANNGDG FVLKKFYDIK PALDVYSSGY
KALSQYIPNS QYIELPEQLS IVISDLRSCL ARANTLESER KEFLQTLEIR SRDNSILPKL
ITEYNSNRSK YQTENGEFNF NAFESVYEKH MKLFDSDIKY IARTRDSQMT LEHEIDSINQ
KFVQEFKSLQ NSSNEKRQQV LQYLETAYEK FLEIINNLTE GSKFYTDFIE KGSAVLQECE
EYLYRRRVES RDLELAISNS FQQQQQVQEQ NEQLSVPRNY SNDKLISPKT SKPGLWNPNS
DIQFS
