ID   PALA_CANGA              Reviewed;         691 AA.
AC   Q6FKK0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=pH-response regulator protein palA/RIM20;
GN   Name=RIM20; OrderedLocusNames=CAGL0L10956g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. May act as a scaffold
CC       protein that recruits the calpain-like protease RIM13 via VPS32 to its
CC       substrate RIM101 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palA/RIM20 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG62218.1; -; Genomic_DNA.
DR   RefSeq; XP_449244.1; XM_449244.1.
DR   AlphaFoldDB; Q6FKK0; -.
DR   SMR; Q6FKK0; -.
DR   STRING; 5478.XP_449244.1; -.
DR   PRIDE; Q6FKK0; -.
DR   EnsemblFungi; CAG62218; CAG62218; CAGL0L10956g.
DR   GeneID; 2891019; -.
DR   KEGG; cgr:CAGL0L10956g; -.
DR   CGD; CAL0134986; CAGL0L10956g.
DR   VEuPathDB; FungiDB:CAGL0L10956g; -.
DR   eggNOG; KOG2220; Eukaryota.
DR   HOGENOM; CLU_007181_3_1_1; -.
DR   InParanoid; Q6FKK0; -.
DR   OMA; SAKHIDD; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR025304; ALIX_V_dom.
DR   InterPro; IPR045251; BRO1-like.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   PANTHER; PTHR23030; PTHR23030; 2.
DR   Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..691
FT                   /note="pH-response regulator protein palA/RIM20"
FT                   /id="PRO_0000218876"
FT   DOMAIN          3..385
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
SQ   SEQUENCE   691 AA;  80474 MW;  12D26B88BD8BAABC CRC64;
     MTELIDIPFL LTKDCSADLE DRLRFCIETG SLYQTHESFK KDIGEIVNTR QALVNLKFGD
     SKLLTKYYGY LECLLKKIDP EALAFSWSYT NYTIFEGNVF RDENLLGERR NILFNLGIAY
     YQSAKHIDDY KNNLPLVCDY LKRSAGCFEI LSQRTKERNS EKAIISETML KALKSMCMGL
     AQETVWFKSL AAKKDLLTSK LAYKCFEYFQ ESLNSFQLVG QSTEYIKLIL VFVESKMLYF
     KAVCVYRLAQ SIESIADNVG VVIRCLSIAV AALTNSKLES TVVFKNKCLE MLRQLEKDND
     FIYLKHVPSH LQFSDFVKLY KLDSMKDLIV LPDLTEIAPS MLDQILFRNL LPIEIMDYGT
     SYNEKQDIYV LQHFVEPINL LNIQLDEELA SFFEIDPQHI VNAHNKTKSF VTRKELDVIG
     QSFGDLESNA INIETQLANI TSYLDLEIKT YEEDKQQYGD VWTIVDARDV TKEFYEKVEK
     LRQYLEIGRN INLETQELFA SIDKSLVTSR TSKAHLTAQY NDPFLNKIEA LKKRRERFIS
     EIEKKSYENR IISKLIMYYK ETDDIPGTIS EREEIFDNIY SKHMKVFAVD MKYIEDCKNE
     NYGLIKEIEE YKSRTNFNNE DRSSDPRTQY IQDVRQSLAS LDDVKTQLKK GTAYYQQLIE
     KVNELVQVIV GFLEARRNDR ERLLNEISTA A