ID   PALA_MAGO7              Reviewed;         849 AA.
AC   Q51NJ3; A4RDY5; G4NE29;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=pH-response regulator protein palA/RIM20;
GN   Name=RIM20; ORFNames=MGG_00833;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. May act as a scaffold
CC       protein that recruits the calpain-like protease RIM13 via VPS32 to its
CC       substrate RIM101 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RIM101 by binding to its two YPX[LI] motifs.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palA/RIM20 family. {ECO:0000305}.
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DR   EMBL; CM001235; EHA48564.1; -; Genomic_DNA.
DR   RefSeq; XP_003718148.1; XM_003718100.1.
DR   AlphaFoldDB; Q51NJ3; -.
DR   SMR; Q51NJ3; -.
DR   STRING; 318829.MGG_00833T0; -.
DR   PRIDE; Q51NJ3; -.
DR   EnsemblFungi; MGG_00833T0; MGG_00833T0; MGG_00833.
DR   GeneID; 2674260; -.
DR   KEGG; mgr:MGG_00833; -.
DR   VEuPathDB; FungiDB:MGG_00833; -.
DR   eggNOG; KOG2220; Eukaryota.
DR   HOGENOM; CLU_007181_0_0_1; -.
DR   InParanoid; Q51NJ3; -.
DR   OMA; SEWIHHM; -.
DR   OrthoDB; 550620at2759; -.
DR   Proteomes; UP000009058; Chromosome 5.
DR   GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR025304; ALIX_V_dom.
DR   InterPro; IPR045251; BRO1-like.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   PANTHER; PTHR23030; PTHR23030; 1.
DR   Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..849
FT                   /note="pH-response regulator protein palA/RIM20"
FT                   /id="PRO_0000218881"
FT   DOMAIN          7..404
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          475..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          260..321
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        475..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        747..777
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..830
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  95377 MW;  45179BB848DB18CC CRC64;
     MSSQSAYQLP ISFRKSNQLS FAPAVRQYIS NKYDQHPDMF RQDIEVIDAL RRDAINVREP
     HTSGIRKLQA YAAQLVWISG KFPIDIGADF TWYPALGYNT DRPLVQNNLQ YELLNVLYNL
     AALYCQLALS TNSNGDSNAI KTAANYFSHA AGVLSHMKTA VLPELRMPSP PEDMDEATLE
     SLEQLMLAQC QECYWQKAVA EGYKDATIAK LAARASDLYN SAAEAAMKSE AISSAWIHHI
     SAKHHHFAAA AQYRASLDCL EKRKYGEEIA RLQDAVACAN EGLREARGGY LKEGVAEDLR
     RLKMRAEEDL KRAEHDNDML YLLPVPTKPE LKILDRANLA VARIPAQVSA PVDHIGDEAE
     FGPALFSKLV PYAVHMAVSI YEERRDRLVN NNIIHELEVL TERMHEILSS LNLPGSLQAL
     EKPLGLPGPL IQHAEEIRQA DGINRIQRSF ADIDKLRSSD IAVFEEGKSL LVTEEEEDQR
     LRRRHGTQRW ARPESRQDPA GGQKLWAQVG EIEGYFASST SSDGIVREKY LAIEDTLMVL
     SGSDRSLMDF VPSSRRTEIP ESVKPALGRL RGAYNDVLRM ESRRRKRVEA LRERARSDDI
     KPDILRETGR LERAYPGTTL AAAHFDDFFE RRLDSLYEDD LALLERETAE QEKCLNEVSR
     VNREFESQRR AAGADKAGGK EREAALQKLD SAFYKYKEIV SNVEVGRKFY NDLSKIVGTF
     RDTCRTWVAE RRKDARSLED EISMPPLGSL SLQQTPSQQS SQYYSQQQQQ QPRSPPQEAH
     HSAYADTGSM PPQQPRPLPA ANAQQTWSQN MPIQFGGPPG TAQQTQPAQA GAKKPVGGTW
     DPSAGIRFG