ID   PALB_CANGA              Reviewed;         713 AA.
AC   Q6FJ28;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Calpain-like protease palB/RIM13;
DE            EC=3.4.22.-;
DE   AltName: Full=Cysteine protease RIM13;
GN   Name=RIM13; OrderedLocusNames=CAGL0M09669g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR380959; CAG62744.1; -; Genomic_DNA.
DR   RefSeq; XP_449766.1; XM_449766.1.
DR   AlphaFoldDB; Q6FJ28; -.
DR   SMR; Q6FJ28; -.
DR   STRING; 5478.XP_449766.1; -.
DR   EnsemblFungi; CAG62744; CAG62744; CAGL0M09669g.
DR   GeneID; 2891330; -.
DR   KEGG; cgr:CAGL0M09669g; -.
DR   CGD; CAL0136251; CAGL0M09669g.
DR   VEuPathDB; FungiDB:CAGL0M09669g; -.
DR   eggNOG; KOG0045; Eukaryota.
DR   HOGENOM; CLU_395483_0_0_1; -.
DR   InParanoid; Q6FJ28; -.
DR   OMA; NISIDTY; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome; Thiol protease.
FT   CHAIN           1..713
FT                   /note="Calpain-like protease palB/RIM13"
FT                   /id="PRO_0000207739"
FT   DOMAIN          74..325
FT                   /note="Calpain catalytic"
FT   ACT_SITE        131
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        308
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   713 AA;  82519 MW;  F3D47DF1E0405685 CRC64;
     MNVDRCWEQY YKTLKLIYLE ENKETCQREI DHLVDTAIEL KEKTYSNAVL DLGRQFREVC
     PKARIMWKTS SIAGNFYPPI SISDIYSPVI ANVFDQTTRL ECRRQEYSLR MPLQEEPNFT
     GIQQHAQVSD CSLVVSLINI NRYKTTMPVV KQVAENLYAT NLYFNGAQRR LVLVSTENIP
     TMQDDPTKQM SVHSANKINK ILELGLLKLT SLSYHSEGSN TAIDTYRLCG WIPDISSINE
     FNFLKVHKAF SRGECLIAMG TGGFVPKENI FGVKLRKYHD YAVLDIDMIN EVVTLRDPLI
     SDTLLTINFD SIRKYFLQVY CNWDSSKLFM FTKDTQIFYS DKKFNPYQTL AGKPTFYLKN
     NSDRDEYAWV LLEFHLDKNN NTTAYLQEIP DRISTVRLGY NDNSAETGFQ LIKIRLKPKQ
     CIWYFCYSST DKMLTFHTYS TSSDVVFVRS KMPGCDFDVT ECAILPENIV PMQYPNHSET
     DIYYLASIDF SIEGEPGITI ITDMVVCLET DDDLVNFQMF HWDDLDFNSP IYDEFYMNER
     MFEKKDLPLT SGERYRIVAS TARPPISKGY QCAVSGINIH ADYPCSYKLR ESDVRYNSMM
     FKLPHVFTLA STGITKISLV NRNKYNKVFM RIYPQTQEDY RYNYRVISAD TGEDLVKPGN
     NIQKLYGGIV IKEFLVSDQT NLELHLSFQD NGRVPVELKC QLYVGSVKII TLS