ID   PALC_CRYNJ              Reviewed;         488 AA.
AC   P0CM48; Q55S47; Q5KGJ9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=pH-response regulator protein palC;
GN   OrderedLocusNames=CNE03350;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palC family. {ECO:0000305}.
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DR   EMBL; AE017345; AAW43591.1; -; Genomic_DNA.
DR   RefSeq; XP_570898.1; XM_570898.1.
DR   AlphaFoldDB; P0CM48; -.
DR   SMR; P0CM48; -.
DR   STRING; 5207.AAW43591; -.
DR   PaxDb; P0CM48; -.
DR   EnsemblFungi; AAW43591; AAW43591; CNE03350.
DR   GeneID; 3257809; -.
DR   KEGG; cne:CNE03350; -.
DR   VEuPathDB; FungiDB:CNE03350; -.
DR   eggNOG; ENOG502QWTM; Eukaryota.
DR   HOGENOM; CLU_027723_0_0_1; -.
DR   InParanoid; P0CM48; -.
DR   OMA; MPSGREY; -.
DR   OrthoDB; 999156at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0071467; P:cellular response to pH; IBA:GO_Central.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR037505; pH-resp_palC.
DR   PANTHER; PTHR40463; PTHR40463; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..488
FT                   /note="pH-response regulator protein palC"
FT                   /id="PRO_0000218886"
FT   DOMAIN          2..430
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          449..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  53186 MW;  BC5B759ECC8759A6 CRC64;
     MPPYLYRLPT TSLITFSAIL NDPSSSYTTI LSDATASRTK LHLALKGIAD NEPGASALAV
     LDAVQIYLPY LKGIIACLDA DELLFKGEPT FQWRAPLTHF SFSSPLLPLA SIHSEHLMVV
     LTYALALSNY AHSILASLPA FEIPAGPKAM PHMSSEDEKR TTAGLARAVD LLCQASGVAE
     WAAENVCLQV EPLKGVSSGR LGKGKWPAES SRETFKALSM ILLADAHLTA IRKLLFPVLT
     YTLFAPPGPP LPPNHPSAPL QAKLYLYVHQ LYSSARALLS VHHQPTSSAP SNSSRKLFRS
     NTDKDVIEPE AVEGEIIPEL KRYLAKEAQL ALALAHKWLG IDAGENGKGA KVGEALAWVK
     DAQGRLEDLE DSKMRAKLKG LSIGKSRERK KEERRARMGR VERELEVVKA WVKAYQKMND
     TVAFQPVPPV SSLVTPSGRP IFGPKAFIPP PSKFSPSRIG HLNEEQGNDS PELGETEDTS
     YAGKGNYF