ID   PALC_EMENI              Reviewed;         507 AA.
AC   Q9P905; C8VBP6; Q5AVX0;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=pH-response regulator protein palC;
GN   Name=palC; ORFNames=AN7560;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10476033; DOI=10.1046/j.1365-2958.1999.01540.x;
RA   Negrete-Urtasun S., Reiter W., Diez E., Denison S.H., Tilburn J.,
RA   Espeso E.A., Penalva M.A., Arst H.N. Jr.;
RT   "Ambient pH signal transduction in Aspergillus: completion of gene
RT   characterization.";
RL   Mol. Microbiol. 33:994-1003(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=3016485; DOI=10.1007/bf00333978;
RA   Caddick M.X., Brownlee A.G., Arst H.N. Jr.;
RT   "Regulation of gene expression by pH of the growth medium in Aspergillus
RT   nidulans.";
RL   Mol. Gen. Genet. 203:346-353(1986).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor pacC in response to alkaline ambient pH.
CC       {ECO:0000269|PubMed:3016485}.
CC   -!- SIMILARITY: Belongs to the palC family. {ECO:0000305}.
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DR   EMBL; AF152925; AAF70857.1; -; Genomic_DNA.
DR   EMBL; AACD01000129; EAA62140.1; -; Genomic_DNA.
DR   EMBL; BN001304; CBF79630.1; -; Genomic_DNA.
DR   RefSeq; XP_680829.1; XM_675737.1.
DR   AlphaFoldDB; Q9P905; -.
DR   STRING; 162425.CADANIAP00000666; -.
DR   EnsemblFungi; CBF79630; CBF79630; ANIA_07560.
DR   EnsemblFungi; EAA62140; EAA62140; AN7560.2.
DR   GeneID; 2869558; -.
DR   KEGG; ani:AN7560.2; -.
DR   VEuPathDB; FungiDB:AN7560; -.
DR   eggNOG; ENOG502QWTM; Eukaryota.
DR   HOGENOM; CLU_023703_0_0_1; -.
DR   InParanoid; Q9P905; -.
DR   OMA; MPSGREY; -.
DR   OrthoDB; 999156at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0000815; C:ESCRT III complex; IMP:AspGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:AspGD.
DR   GO; GO:0071467; P:cellular response to pH; IMP:AspGD.
DR   GO; GO:0042318; P:penicillin biosynthetic process; IMP:AspGD.
DR   GO; GO:1900198; P:positive regulation of penicillin biosynthetic process; IMP:AspGD.
DR   GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR037505; pH-resp_palC.
DR   PANTHER; PTHR40463; PTHR40463; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..507
FT                   /note="pH-response regulator protein palC"
FT                   /id="PRO_0000218887"
FT   DOMAIN          1..288
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          375..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        325..326
FT                   /note="EL -> DV (in Ref. 1; AAF70857)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   507 AA;  54608 MW;  6FFD5FF0237D2F3F CRC64;
     MVYPFELPTT SHLSFQSALS SHTHPSLPQS ATTARHALRL ALKAHNRLPR GFQRDSHLTS
     VLSAINDYLP YVVALAQGLN NGKPIDTTTP STTTHLEEIR VAQRAELEPE WRATLASSSL
     RRPSTNRTRG TGVQYELAFI LTTLGYILSS LARSGVTRTL YASTTPSAEQ RTAAVQTATK
     HLLQASTIHS FLSSSPYFAT VSEAATLPDL APATQAALSS LALAEATLLT VLKDDSYVVA
     CIQARNPNDK DWMVRAPEIP KVRAHLFARL CIRAAEYAEQ AATGLSSVAA EGRKAGVDED
     VARYAHVLGL VARARACRFF GVDAELAGKV GEGIAWLRAA KGALGLRNTG SASAEEVTTK
     SRGLSKLKLG FRERREERKL EKGAGGERVD KGGLGPGDNA GREEEGRVLE MLETKWVRAN
     DTLNTQLIPS SADYVANLPS GRDVLPPQPP YTPPSLDEER LFQMRGPPTE LELNPGSDDG
     DSDFESQAAG DAHTPGAFPG RADNAYY