ID   PALC_NEUCR              Reviewed;         490 AA.
AC   Q7SEM8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=pH-response regulator protein palC;
GN   Name=palc-1; ORFNames=NCU03316;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor pacc-1 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002236; EAA35257.1; -; Genomic_DNA.
DR   RefSeq; XP_964493.1; XM_959400.2.
DR   AlphaFoldDB; Q7SEM8; -.
DR   STRING; 5141.EFNCRP00000002917; -.
DR   EnsemblFungi; EAA35257; EAA35257; NCU03316.
DR   GeneID; 3880642; -.
DR   KEGG; ncr:NCU03316; -.
DR   VEuPathDB; FungiDB:NCU03316; -.
DR   HOGENOM; CLU_023703_0_0_1; -.
DR   InParanoid; Q7SEM8; -.
DR   OMA; MPSGREY; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0071467; P:cellular response to pH; IBA:GO_Central.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR037505; pH-resp_palC.
DR   PANTHER; PTHR40463; PTHR40463; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..490
FT                   /note="pH-response regulator protein palC"
FT                   /id="PRO_0000218889"
FT   DOMAIN          1..299
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          342..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  53450 MW;  3E75398470DC8043 CRC64;
     MPYPFVLPTT SSFSFTSCFS CESHPSLPLN ASTRRGVVRE DLKAFKRTPR EHQVAKLPTV
     VSSLIAYLPY LFAVDAGLSQ QAINGEEIAV ILKTAPIIEW RPTLSDNAAV AVPGKDPARV
     KVHSLEYEVF FVLSCLANAH TLQARTALHP LYVLSTAPVG TQQRQVAVSA ATKNLLDAAS
     IYDYLALRAE GLSSGYGMAP PCADISPAAL RAQCSLAMAE ATLLAVLKDD PYPAVVAQDR
     NKNDTEWMYK APDIPKVRAH LFARLCLAAS EHAAQAYSLC AGLARAEGGA KVTESFLKYL
     DNLRRTSRAK ACRFFGIDSE LGGQTGTAIA WLNAGLQELG VERNPSEGGS KRSGGLGRLK
     EKWTEKREDK KVERGLDWGA DAGRLEESRV YEMLWEKWSK QNDTIMTQVV PPSGPLLQQM
     PMGREIHTLK PFQPPQLDPP TLEAMRAPPE RSDDAALYPS SDEDDTMIGA TIGAFPGTQG
     HFRTGTPNYF