ID   PALD_DANRE              Reviewed;         860 AA.
AC   Q803E0; Q6NY33;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Paladin;
GN   Name=pald1; Synonyms=pald;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paladin family. {ECO:0000305}.
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DR   EMBL; BC044521; AAH44521.1; -; mRNA.
DR   EMBL; BC066756; AAH66756.1; -; mRNA.
DR   RefSeq; NP_942106.1; NM_198811.1.
DR   AlphaFoldDB; Q803E0; -.
DR   GeneID; 368369; -.
DR   KEGG; dre:368369; -.
DR   CTD; 368369; -.
DR   ZFIN; ZDB-GENE-030804-26; pald1a.
DR   InParanoid; Q803E0; -.
DR   OrthoDB; 197637at2759; -.
DR   PhylomeDB; Q803E0; -.
DR   PRO; PR:Q803E0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IMP:ZFIN.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   SUPFAM; SSF52799; SSF52799; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipoprotein; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..860
FT                   /note="Paladin"
FT                   /id="PRO_0000286133"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        222
FT                   /note="H -> Y (in Ref. 1; AAH66756)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        295
FT                   /note="L -> P (in Ref. 1; AAH66756)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        654
FT                   /note="A -> V (in Ref. 1; AAH66756)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        821
FT                   /note="L -> H (in Ref. 1; AAH66756)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   860 AA;  98885 MW;  680AD3E0BC07C270 CRC64;
     MGTTASAAPQ ATLHERLHSD SMTDSRRSIQ TLGIHNNKAK SIITNKVAPV VITYNCRQEF
     QIHDDVLRTN YKVGRISDNM PEHHLVQGSF FMVQDVFSKA DVLNTTASYG APNFRQSGGG
     FPLYGMGQTS LGGFKRVLES LQTRGHQEVI FFCLREEPVV FLHLQEDFLP YTPRRKENLH
     ENLQHLQRGA SSEDLELTIR KELHDFAKLN DNMFYVYNDI EHLKGEPQKI CICSEEDIHI
     TEEVYRRPRF TMPAYRYYRL PLPMEGAPME EQFDAFVKVL RENPSLSLNR DASRLLPALL
     FSCQVGVGRT NLGLILGTLV MMHLTRTTAE KTTPAEEEVK DEHKIQFRVI ESLIGKLPKG
     QEVMEEVNRA IDLCSEMHDI RESIYENKQK LEGIGEDYQT QGSSTKDYFL HGALQSLERY
     FYLIVFNAYL HEQYPLAFAC SFSQWLCSNA WIYRLLSCMN QSELRAPADL VTKGARVLVA
     DEYLAPDVLS TIKEMKVANF RRVPKMSIYG MAQPTSEAAS VVLAYLCDEK RKHSSVLWVN
     LQDELLLEAN NQIFSPREPT RVEQCIRVCS AQPEDIQSLE ASLKAQLLAS QQWLEVTLEQ
     EKQMKMIKSC STVQEIFNQL KSSHHALQYR RIPFPECSAP SEEGFDQLLD VMKATLAEDS
     LSAFVFNCSN GKARTTTAMV IATLTLWHFN GFPEFCEDEI VSVPDAKYTK GEFEVVMKLV
     RLLPDGQRMK REVDAALDSV SETMTPLHYH LREIIICTYR QIRSCKSDAE LLALQALLYL
     ERYIYLILYN SYLHLEKRDS WRRPFSVWMQ QVAAPAGVYE LLNQLGFSEF EDLRDSTLCR
     LRRRWLQQNR HGLPFRGELI