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PALD_HUMAN
ID   PALD_HUMAN              Reviewed;         856 AA.
AC   Q9ULE6; B2RMS1; B9EGC6; Q5JTK7; Q5JTK8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 3.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Paladin;
GN   Name=PALD1; Synonyms=KIAA1274, PALD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-141.
RC   TISSUE=Brain;
RX   PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA   Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XV. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:337-345(1999).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-141.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   MYRISTOYLATION AT GLY-2.
RX   PubMed=20213681; DOI=10.1002/pmic.200900783;
RA   Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA   Tsunasawa S., Utsumi T.;
RT   "Strategy for comprehensive identification of human N-myristoylated
RT   proteins using an insect cell-free protein synthesis system.";
RL   Proteomics 10:1780-1793(2010).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [7]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=22354871; DOI=10.1002/dvdy.23753;
RA   Wallgard E., Nitzsche A., Larsson J., Guo X., Dieterich L.C., Dimberg A.,
RA   Olofsson T., Ponten F.C., Makinen T., Kalen M., Hellstrom M.;
RT   "Paladin (X99384) is expressed in the vasculature and shifts from
RT   endothelial to vascular smooth muscle cells during mouse development.";
RL   Dev. Dyn. 241:770-786(2012).
CC   -!- INTERACTION:
CC       Q9ULE6; Q92985: IRF7; NbExp=2; IntAct=EBI-3957166, EBI-968267;
CC       Q9ULE6; A2APF7: Zbp1; Xeno; NbExp=2; IntAct=EBI-3957166, EBI-6115394;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22354871}.
CC   -!- TISSUE SPECIFICITY: Expressed in endothelial cells, and in certain
CC       larger vessels, in mural cells. In the brain, possibly expressed in
CC       microglia. Expressed in peripheral blood mononuclear cells (at protein
CC       level). {ECO:0000269|PubMed:22354871}.
CC   -!- SIMILARITY: Belongs to the paladin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA86588.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB033100; BAA86588.2; ALT_INIT; mRNA.
DR   EMBL; AC022532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC136375; AAI36376.1; -; mRNA.
DR   EMBL; BC136376; AAI36377.1; -; mRNA.
DR   CCDS; CCDS31215.1; -.
DR   RefSeq; NP_055246.2; NM_014431.2.
DR   RefSeq; XP_011537939.1; XM_011539637.2.
DR   RefSeq; XP_011537940.1; XM_011539638.2.
DR   RefSeq; XP_016871561.1; XM_017016072.1.
DR   AlphaFoldDB; Q9ULE6; -.
DR   BioGRID; 118028; 92.
DR   ELM; Q9ULE6; -.
DR   IntAct; Q9ULE6; 17.
DR   MINT; Q9ULE6; -.
DR   STRING; 9606.ENSP00000263563; -.
DR   DEPOD; PALD1; -.
DR   GlyGen; Q9ULE6; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9ULE6; -.
DR   PhosphoSitePlus; Q9ULE6; -.
DR   BioMuta; PALD1; -.
DR   DMDM; 146325028; -.
DR   EPD; Q9ULE6; -.
DR   jPOST; Q9ULE6; -.
DR   MassIVE; Q9ULE6; -.
DR   MaxQB; Q9ULE6; -.
DR   PaxDb; Q9ULE6; -.
DR   PeptideAtlas; Q9ULE6; -.
DR   PRIDE; Q9ULE6; -.
DR   ProteomicsDB; 85011; -.
DR   Antibodypedia; 2835; 100 antibodies from 20 providers.
DR   DNASU; 27143; -.
DR   Ensembl; ENST00000263563.7; ENSP00000263563.5; ENSG00000107719.9.
DR   GeneID; 27143; -.
DR   KEGG; hsa:27143; -.
DR   MANE-Select; ENST00000263563.7; ENSP00000263563.5; NM_014431.3; NP_055246.2.
DR   UCSC; uc001jrd.5; human.
DR   CTD; 27143; -.
DR   DisGeNET; 27143; -.
DR   GeneCards; PALD1; -.
DR   HGNC; HGNC:23530; PALD1.
DR   HPA; ENSG00000107719; Low tissue specificity.
DR   MIM; 614656; gene.
DR   neXtProt; NX_Q9ULE6; -.
DR   OpenTargets; ENSG00000107719; -.
DR   PharmGKB; PA134986569; -.
DR   VEuPathDB; HostDB:ENSG00000107719; -.
DR   eggNOG; ENOG502QQ90; Eukaryota.
DR   GeneTree; ENSGT00390000005448; -.
DR   HOGENOM; CLU_008167_0_0_1; -.
DR   InParanoid; Q9ULE6; -.
DR   OMA; WLCTHPE; -.
DR   OrthoDB; 197637at2759; -.
DR   PhylomeDB; Q9ULE6; -.
DR   TreeFam; TF332292; -.
DR   PathwayCommons; Q9ULE6; -.
DR   SignaLink; Q9ULE6; -.
DR   BioGRID-ORCS; 27143; 8 hits in 1062 CRISPR screens.
DR   ChiTaRS; PALD1; human.
DR   GenomeRNAi; 27143; -.
DR   Pharos; Q9ULE6; Tbio.
DR   PRO; PR:Q9ULE6; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9ULE6; protein.
DR   Bgee; ENSG00000107719; Expressed in tendon of biceps brachii and 126 other tissues.
DR   ExpressionAtlas; Q9ULE6; baseline and differential.
DR   Genevisible; Q9ULE6; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Lipoprotein; Myristate; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..856
FT                   /note="Paladin"
FT                   /id="PRO_0000286130"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         86
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70261"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000269|PubMed:20213681"
FT   VARIANT         141
FT                   /note="S -> L (in dbSNP:rs2275060)"
FT                   /evidence="ECO:0000269|PubMed:10574462,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_032076"
FT   VARIANT         721
FT                   /note="R -> C (in dbSNP:rs3740447)"
FT                   /id="VAR_032077"
FT   VARIANT         828
FT                   /note="G -> R (in dbSNP:rs10999406)"
FT                   /id="VAR_062188"
SQ   SEQUENCE   856 AA;  96754 MW;  BFCDD78DB2D4BE3B CRC64;
     MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS IIPNKVAPVV
     ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA
     PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY
     TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA
     IHGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD
     AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS
     FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRPESPAQG SGSRHSVWQR
     ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA
     RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR
     KVVWVSLREE AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF
     QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS
     CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH
     RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRRLQLR SLQYLERYVC
     LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW
     QEQSCSLEPS APEDLL
 
 
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