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PALD_MOUSE
ID   PALD_MOUSE              Reviewed;         859 AA.
AC   P70261; Q66JP9; Q8C2I4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Paladin;
GN   Name=Pald1; Synonyms=Pald;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pearce J.J.H., Davies T., Gardener R.L.;
RT   "A subtractive screen of mouse gastrulation.";
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-257.
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 51-58, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=22354871; DOI=10.1002/dvdy.23753;
RA   Wallgard E., Nitzsche A., Larsson J., Guo X., Dieterich L.C., Dimberg A.,
RA   Olofsson T., Ponten F.C., Makinen T., Kalen M., Hellstrom M.;
RT   "Paladin (X99384) is expressed in the vasculature and shifts from
RT   endothelial to vascular smooth muscle cells during mouse development.";
RL   Dev. Dyn. 241:770-786(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Vascular expression detected in the central nervous
CC       system, kidney, lung, heart, skeletal muscle, white adipose tissue
CC       (WAT), brown adipose tissue, liver, pancreas and spleen. Not expressed
CC       in all vessels: for instance, not expressed in capillaries in the
CC       brain, and expressed mainly in large vessels in the heart, WAT, liver,
CC       pancreas and kidney. Predominant nonvascular expression in myocardium
CC       and lung mesenchyme. In large vessels, primarily expressed by smooth
CC       muscle cells, but occasionally detected at low levels in the
CC       endothelium. Expressed in various cells of the hematopoietic lineage.
CC       {ECO:0000269|PubMed:22354871}.
CC   -!- DEVELOPMENTAL STAGE: At 9.5 and 10.5 dpc, weak but general expression
CC       in the intersomitic mesenchyme. Higher levels of expression in the
CC       intersomitic vessels and other developing small and large blood
CC       vessels. Expressed in the notochord and the roof and floor plates of
CC       the neural tube. Expressed along rhombomeres 2 and 4, as well as
CC       pharyngeal arches 1 and 2, possibly in neural crest cells. No
CC       expression in the somites. At 14.5 dpc, predominantly expressed in all
CC       vessels, capillaries (at protein level), arteries and veins. Strong
CC       vascular expression observed in neural tissue, skeletal muscle, skin,
CC       kidney, liver, and along the gastrointestinal tract. Nonvascular
CC       expression detected in heart myocardium, lung and kidney mesenchyme (at
CC       protein level). During postnatal vascular development, expression
CC       shifts from capillary and venous vessels to arteries, from endothelial
CC       cells to vascular smooth muscle cells. {ECO:0000269|PubMed:22354871}.
CC   -!- SIMILARITY: Belongs to the paladin family. {ECO:0000305}.
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DR   EMBL; X99384; CAA67763.1; -; mRNA.
DR   EMBL; AK088577; BAC40433.1; -; mRNA.
DR   EMBL; BC080827; AAH80827.1; -; mRNA.
DR   EMBL; BC099531; AAH99531.1; -; mRNA.
DR   CCDS; CCDS23877.1; -.
DR   RefSeq; NP_038781.2; NM_013753.2.
DR   AlphaFoldDB; P70261; -.
DR   STRING; 10090.ENSMUSP00000020289; -.
DR   iPTMnet; P70261; -.
DR   PhosphoSitePlus; P70261; -.
DR   MaxQB; P70261; -.
DR   PaxDb; P70261; -.
DR   PeptideAtlas; P70261; -.
DR   PRIDE; P70261; -.
DR   ProteomicsDB; 294153; -.
DR   DNASU; 27355; -.
DR   GeneID; 27355; -.
DR   KEGG; mmu:27355; -.
DR   CTD; 27143; -.
DR   MGI; MGI:1351623; Pald1.
DR   eggNOG; ENOG502QQ90; Eukaryota.
DR   InParanoid; P70261; -.
DR   OrthoDB; 197637at2759; -.
DR   PhylomeDB; P70261; -.
DR   TreeFam; TF332292; -.
DR   BioGRID-ORCS; 27355; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Pald1; mouse.
DR   PRO; PR:P70261; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P70261; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Lipoprotein; Myristate;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..859
FT                   /note="Paladin"
FT                   /id="PRO_0000286131"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        262
FT                   /note="L -> F (in Ref. 2; BAC40433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="H -> R (in Ref. 2; BAC40433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="P -> A (in Ref. 2; BAC40433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        549
FT                   /note="F -> N (in Ref. 2; BAC40433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        578
FT                   /note="V -> E (in Ref. 2; BAC40433)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   859 AA;  96740 MW;  EDD68ED03F1B8A7B CRC64;
     MGTTASTAQQ TVSAGTSLEG LQGGSSSSMD SQHSLGGVQS FRATSLHNSK AKSIIPNKVA
     PVVITYNCKE EFQIHDELLK AHYRMGRLSD ATPEHYLVQG RYFLVRDITE KMDILGTLKS
     CGAPNFRQVR GGLPVFGMGQ PSLLGFRRVL QKLQTDGLKE CIIFCVREEP VVFLRAEEDF
     VSYTPRDKES LHENLRDPSP GVKAENLELA IQKEIHDFAQ LRDNVYHVYH NTEDLRGEPH
     TVAIRGEDGV CVTEEVFKRP LLLQPTYRYH HLPLPEQGPP LEAQFDAFVS VLRETPSLLP
     LRDNHGPLPA LLFSCQSGVG RTNLGMVLGT LVMFHHSRTT SQLEAASPLA KPLPMEQFQV
     IQGFICKVPQ GKKMVEEVDR AISACAELHD LKEEVLKNQR RLESFRPESR GQECGSQQAV
     QQRALWSLEL YFYLLLFNYY LHEQYPLAFA LSFSRWLCTH PELYRLLVEL NSVGPLVPGD
     LIAKGSLEAD DLVSLDALST VREMDVANFR RVPRMPIYGT AQPSAKALGN ILAYLSDAKR
     KLRQVVWIFL REEVVLECDG HTHSLWPPGP ALAPEHLVAL EAQLKAHLSA PVPNTKSPTA
     PRFQKCLTTQ EVFSQHQGAC LGLTYCRIPV PDFCAPREED FDRLLEALRA ALTKDPGTGF
     VFSCLSGQGR TTTAMVVAVL ACWHIGGCPE VGEEELVSVP DAKFTKGEFQ VVMKVVQLLP
     DGHHVKKEVD AALDIVSETM TPMHYHLREI IISTYRQAKA TKEAQEAQRL QLRSLQYLER
     YIYLILFNAY LRLEKTSSWQ RPFSTWMREV ATKAGIYEIL NQLGFPELES IEEQPLSRLR
     YRWQEQSRDP EPCDVGDFL
 
 
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