ID   PALF_ASHGO              Reviewed;         548 AA.
AC   Q754G2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=pH-response regulator protein palF/RIM8;
GN   Name=RIM8; OrderedLocusNames=AFR108W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS53479.1; -; Genomic_DNA.
DR   RefSeq; NP_985655.1; NM_211009.1.
DR   AlphaFoldDB; Q754G2; -.
DR   STRING; 33169.AAS53479; -.
DR   EnsemblFungi; AAS53479; AAS53479; AGOS_AFR108W.
DR   GeneID; 4621898; -.
DR   KEGG; ago:AGOS_AFR108W; -.
DR   eggNOG; ENOG502QTQN; Eukaryota.
DR   HOGENOM; CLU_006001_1_0_1; -.
DR   InParanoid; Q754G2; -.
DR   OMA; GMSIEIV; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0016485; P:protein processing; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..548
FT                   /note="pH-response regulator protein palF/RIM8"
FT                   /id="PRO_0000058185"
FT   REGION          439..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          497..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  60351 MW;  DA45828B486F2FEF CRC64;
     MHMRLFSKFK LHGSSAASEE VFGGKFSYTS AVADFYIELG DAHKIWKPRD VVTGEVVLTL
     RKPLRGVSLR MSLEGNLRVQ TGSGATSRLK FQRTLFSKSS MIYGVEQPED AEQEGHGLTR
     GDHRFPFRMR VPSKNIYTSI AFEKGSISYA VGCVLETRSG AQRLSSCSRQ ISVLVPVDVS
     LLPKLRPKTV VLQSPQLLRS AKANYPEHDT ASSLTKRTTA SANSNSSVTT VCSSKTVTIS
     VDLPESGYVI GDTIRIKVHI QHYKEYRNSA GLIATLVRIC RVHSTGTDDP METFRKDICQ
     CVAPLYVEPE THTCSVGMNL NVPLDAFPTL VVPNQGFTFQ YYIEVLANLS SKNIVYTESN
     RVIGGSGMAD IPMPGSKLHP VKKISMLPLK LQGPLGKQDT NIDESLIFFQ DMVNVDKLKR
     LRNVTGTSIE VVIGTHRNNS VQQARQSCPG SPVGGSDSTM MSEQSAAGTS LPSSVLDIYD
     QLANRLSSSV GDQLLRYGMS PDSGPHSAND ELPRYTPNVD YMVTEDKREL EQRKLKELES
     EPSVEEEQ