ID   PALF_CANAL              Reviewed;         622 AA.
AC   Q9UW13; A0A1D8PC62; Q5AB81;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=pH-response regulator protein palF/RIM8;
GN   Name=RIM8; Synonyms=PRR1; OrderedLocusNames=CAALFM_C100150CA;
GN   ORFNames=CaO19.13510, CaO19.6091;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / CAI4 / ATCC MYA-682;
RX   PubMed=10629054; DOI=10.1128/mcb.20.3.971-978.2000;
RA   Davis D.A., Wilson R.B., Mitchell A.P.;
RT   "RIM101-dependent and -independent pathways govern pH responses in Candida
RT   albicans.";
RL   Mol. Cell. Biol. 20:971-978(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [5]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=10601209; DOI=10.1128/jb.181.24.7516-7523.1999;
RA   Porta A., Ramon A.M., Fonzi W.A.;
RT   "PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene
RT   expression and filamentation in Candida albicans.";
RL   J. Bacteriol. 181:7516-7523(1999).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. Required for hyphal
CC       development. {ECO:0000269|PubMed:10601209}.
CC   -!- INDUCTION: Induced at acidic pH. {ECO:0000269|PubMed:10601209}.
CC   -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD51715.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF173842; AAD51715.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CP017623; AOW25717.1; -; Genomic_DNA.
DR   RefSeq; XP_719051.1; XM_713958.1.
DR   AlphaFoldDB; Q9UW13; -.
DR   SMR; Q9UW13; -.
DR   STRING; 237561.Q9UW13; -.
DR   PRIDE; Q9UW13; -.
DR   GeneID; 3639342; -.
DR   KEGG; cal:CAALFM_C100150CA; -.
DR   CGD; CAL0000197201; RIM8.
DR   VEuPathDB; FungiDB:C1_00150C_A; -.
DR   eggNOG; ENOG502QTQN; Eukaryota.
DR   HOGENOM; CLU_006001_1_0_1; -.
DR   InParanoid; Q9UW13; -.
DR   OMA; YEDYYPK; -.
DR   OrthoDB; 817924at2759; -.
DR   PHI-base; PHI:186; -.
DR   PRO; PR:Q9UW13; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0071467; P:cellular response to pH; IMP:CGD.
DR   GO; GO:0044409; P:entry into host; IMP:CGD.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR   GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:0036177; P:filamentous growth of a population of unicellular organisms in response to pH; IMP:CGD.
DR   GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR   GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..622
FT                   /note="pH-response regulator protein palF/RIM8"
FT                   /id="PRO_0000058186"
FT   REGION          210..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  69252 MW;  3CFE1BDF66754A8A CRC64;
     MRRAVSKILP TPKLFNDSAH FHSNFRLEYN SVDDFYVQLD NPHKVWLPGE EISGQVVLIS
     KKNLANIVIT LSLVGFIKIN ASSHSKLRPL KHTLFDYTIK IYGKDEEEQT DSAEFSNGLL
     KGEHVFPFIV KLPNKRVYTS IDFGKGSINY ILKAAIGNSS SYVIPASPDN ASTSSLTKKK
     ILQNPSHTSE KVISLVNPID VSLLPRPKPK RLILKDPRTS SNKKLSRTQT STSTINTMSS
     NEHDHSLPEG ATPEDSDHKS LKSIPVPTIK AILEVPQRGY LRGESIPIKL SINHLRKIQD
     FNGIIITFVR VCRLDNGPDG VVESFRKDLQ QLILPLYVDP VTFQSEINSS LRVPADAFPT
     ILGCPLVSFQ YFVEVLINLS GKSIALDSDV DARAKANPQA TKSSSDKFKF NFDSTQTERS
     TYINTDSYKR SKKFLQLTTE IYIGTHRSST QEEQAPQAEE VASRRSSSMA SNSNSSPAVF
     STSSPHSPVE HQYAGAINSI PESVAVSNFT PPYENVVPSY VPPEFVSHLQ NQSELSEKER
     MRQHESSLLP SAPPDDEQPS PVNMTSNQQP FSFFTYQNTN TSPPVPLDDD LYQEPVDSAP
     NYLNVNNDRL IVPQDNNSNS ET