ID   PALF_EMENI              Reviewed;         775 AA.
AC   P78612; C8VPQ7; Q5BC86;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=pH-response regulator protein palF/RIM8;
GN   Name=palF; ORFNames=AN1844;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=9272857; DOI=10.1016/s0378-1119(97)00095-4;
RA   Maccheroni W. Jr., May G.S., Martinez-Rossi N.M., Rossi A.;
RT   "The sequence of palF, an environmental pH response gene in Aspergillus
RT   nidulans.";
RL   Gene 194:163-167(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=3016485; DOI=10.1007/bf00333978;
RA   Caddick M.X., Brownlee A.G., Arst H.N. Jr.;
RT   "Regulation of gene expression by pH of the growth medium in Aspergillus
RT   nidulans.";
RL   Mol. Gen. Genet. 203:346-353(1986).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor pacC in response to alkaline ambient pH.
CC       {ECO:0000269|PubMed:3016485}.
CC   -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U56696; AAC49808.1; -; mRNA.
DR   EMBL; AACD01000029; EAA65009.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF85673.1; -; Genomic_DNA.
DR   RefSeq; XP_659448.1; XM_654356.1.
DR   AlphaFoldDB; P78612; -.
DR   STRING; 162425.CADANIAP00008495; -.
DR   PRIDE; P78612; -.
DR   EnsemblFungi; CBF85673; CBF85673; ANIA_01844.
DR   EnsemblFungi; EAA65009; EAA65009; AN1844.2.
DR   GeneID; 2874855; -.
DR   KEGG; ani:AN1844.2; -.
DR   VEuPathDB; FungiDB:AN1844; -.
DR   eggNOG; ENOG502QTQN; Eukaryota.
DR   HOGENOM; CLU_006001_0_0_1; -.
DR   InParanoid; P78612; -.
DR   OMA; YEDYYPK; -.
DR   OrthoDB; 817924at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0071467; P:cellular response to pH; IMP:AspGD.
DR   GO; GO:0042318; P:penicillin biosynthetic process; IMP:AspGD.
DR   GO; GO:1900198; P:positive regulation of penicillin biosynthetic process; IMP:AspGD.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..775
FT                   /note="pH-response regulator protein palF/RIM8"
FT                   /id="PRO_0000058189"
FT   REGION          217..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..650
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..758
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  84087 MW;  92D458A986F98B58 CRC64;
     MVRATCSCVM SVNPLSAQTS ASPLSRNRSS LLSKFRTQLG QRNRAITDFY IEPDDPWRSY
     FPGDVIKGTV SLTVVRPVRI THLVISLHGI VKVFKNNVPA GETPPDVGSL GPGRGRRGAE
     YLGNGVATLF EDEVVLCGEG RLKEGIYKFR FEMSFPPYPL PSSISFERGT ISYMLTSTLT
     KPTTMNPTLS CRRRINLLEN IDIAAFPAPK PRVVTLEPIS KRSKPKGKTK AAGFDAPDTA
     SLEPSASGGI TVPEHRPPLS PAPSNVSSSS RLSNSSQSFQ IVTDPGSTAS SGVRNSEARS
     NTPSVTDGII TAKAEVLRAG VLPGDTLPIK ITINHTKQVR SAHGIIITLY RSGRIDLHPA
     IPMGSTANGK KPIYEDYYPR SRTGLGGLTL GTSRASSVFR KDLSQTFAPL IVDPTTLTAD
     IKTSIRIPED AFPTITRTPG SMINFRYYVE VVVDLRGKLT SPERFLPRFN LVSSGRNFSS
     NGKIVHPADT NGSAITANWG DNILDTDQIR REKGVVAVIF EVVIGTQDTQ RRKSEARRMS
     STAEEAEFQQ PVENSVDGDY AGHDYQGSMA GPEPGYAPLE NTAYGPDQIR WPDYPEQSEH
     EHYPFQPGTL PSPQPDEPMD EKARLRRAEQ TLLPSQPPCD PEAGPSSAVE AAMPTAPVLP
     EDDHLNDYHH LPSTTVNGMT GMAPALMSAE SVQTVIAGSS SAPLTSPSRP SEEDKQELER
     QRLMMEASAP GDPDARHNDR ADDGPSAPIF HDDDDDQQLV GGAANGDELL PRYQR