ID   PALF_KLULA              Reviewed;         572 AA.
AC   Q6CTM7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=pH-response regulator protein palF/RIM8;
GN   Name=RIM8; OrderedLocusNames=KLLA0C11473g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR382123; CAH01563.1; -; Genomic_DNA.
DR   RefSeq; XP_452712.1; XM_452712.1.
DR   AlphaFoldDB; Q6CTM7; -.
DR   SMR; Q6CTM7; -.
DR   STRING; 28985.XP_452712.1; -.
DR   EnsemblFungi; CAH01563; CAH01563; KLLA0_C11473g.
DR   GeneID; 2891841; -.
DR   KEGG; kla:KLLA0_C11473g; -.
DR   eggNOG; ENOG502QTQN; Eukaryota.
DR   HOGENOM; CLU_006001_1_0_1; -.
DR   InParanoid; Q6CTM7; -.
DR   OMA; GMSIEIV; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0016485; P:protein processing; IEA:EnsemblFungi.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:EnsemblFungi.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..572
FT                   /note="pH-response regulator protein palF/RIM8"
FT                   /id="PRO_0000058190"
FT   REGION          221..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  63684 MW;  5309DAB89AF1B46D CRC64;
     MGLFDKLLRS NERAERGSPS AFVVSSFDSV SNAGKSSIFK HSGMKSYILE FEIVLDDVHR
     VWKPNETISG TVKLRLRKDV PNVWIKLAHI GEFQLHSNNP MTAGSLKSKY SDTVFCRSTS
     IYGSEENPLH LTGGEHKFPF SCKINGKNLV SSIDFKKGSI RYWVQAELHA QKTPPIFCKQ
     HYQLIVPIDV GQLPKPNIKT VVLQSPNSSN NGIHVRRLMA AGSADPQDGA SSLTRKTGGS
     STITNGSSSS NNSGNSNASM LADNKTVKIS VEIPCLGYTI GEEIPVKVHV THYKQYFHPA
     GLIATLVRIS RVSNPRNTEQ IETFRKDICQ GVAPLYTDPE THEAVIMLKL KVPLDTFPSL
     DLKNKFFTFQ YYVEILANLS RKNLVYTESN RLVGGQRTSS IPMPSNKFSM FQDLSNQGEV
     TAGEDDSVTF FQDLINVDRL KRLRNVTGMS IEVVIGTHRE EHEPESPTVD RLDSHSINQL
     PDDVDAVYNQ CSSAESPIDE AYDYLLHRHN GPSPSSRIFT DTDMTLCYPA DPVPLYSRGL
     DDFTGCSMSG VTDDKQELEQ MRLKELESEP PI