ID   PALF_NEUCR              Reviewed;         962 AA.
AC   Q7SGZ5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=pH-response regulator protein palF/prr-3;
DE   AltName: Full=pH-response regulator 3;
GN   Name=prr-3; Synonyms=rim8; ORFNames=B18P24.140, NCU03021;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor pacc-1 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the arrestin family. PalF/RIM8 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE76272.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX842626; CAE76272.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002236; EAA36171.2; -; Genomic_DNA.
DR   RefSeq; XP_965407.2; XM_960314.2.
DR   AlphaFoldDB; Q7SGZ5; -.
DR   STRING; 5141.EFNCRP00000002470; -.
DR   PRIDE; Q7SGZ5; -.
DR   EnsemblFungi; EAA36171; EAA36171; NCU03021.
DR   GeneID; 3881557; -.
DR   KEGG; ncr:NCU03021; -.
DR   VEuPathDB; FungiDB:NCU03021; -.
DR   HOGENOM; CLU_006001_0_0_1; -.
DR   InParanoid; Q7SGZ5; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 1.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..962
FT                   /note="pH-response regulator protein palF/prr-3"
FT                   /id="PRO_0000058192"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          689..962
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..288
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..597
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..655
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..807
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        836..851
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..950
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   962 AA;  102830 MW;  EA418F9FE168D376 CRC64;
     MGPFSSASDR NSAAATAAPA TATATPSPLS KTPSAATSDD SSTSKKFLKR LNILPLRSRT
     RNIADFHIRP DDPHRKYSAG DHVQGAVVLT VVKPVRITHL TVLLHGYVRV YKGPGAQNNE
     PVRSPAEIKN ISSRGERKKY YNGYASLFQD EQVLSSDGRL EPGRYEFNFD LLFPEKGLPS
     SIDFERGTIS YMITATLTRP TSVAPTTSCE RKIYLMEQLD VGPLAPPKAQ TVDLRPISKR
     AKKKRPAGGD RRSVISSERL SADVPAESLS DGDSARINDT STEGSLSIVG DDVGQEGFSQ
     APRSVSHSEV RSLSGDSAAS LSTHPSRAYS ETNQLAIVGS AMTGKRISFA DERTIKLRVE
     VLKGGCLPGD VIPVKVSVNH IKMIKSMHGV IVTLFRQGRI DSSPLQLSKE DWKKSESDDY
     YYPKSRTGLS GLSLSSAGSC SMFRKDLSQA FAPLITDPVN FSATLTTSVR VPEDSFPTIK
     GVPGEMISFR YFVEVIVDLG GKLANHLQGG ASSGSRVGAT GVVGTPFENV GTLPSWGATG
     STSILDTDRL KRIQGVIPGY YEVIVGTTDS NRSRGKGPQR PSLTHTPSVT GGSNYVENEY
     NEKGGWPNSM HDDDGYGPES ANPHDDYASY PPQTTYPHGY VQQPPYWNYV PDSSQHEQAI
     PAPHYIPPPD LPDENSLTEK ERIRRAEQRL LPSQPPIAAA SSSSFSAAVP SPSASSHVPD
     SSLLLNGDNI YDAEDDVPTP AATPATASPF DHALAPVYTP TPAEDLPSAP TLEELDRPPP
     ISRGPSHHPP STTEDKQELE RRRLLAEASA PPEFPEDYIP DEGGGPVTPA GPSGSRAGPS
     APPPAPPVAF EPSAPVLFEN DEDYHGGGYT AGGPSFPSAA SGNGGHEEET VPEYTYNNHR
     PGSVGAVTVV GNPSSPVLAP ASAFFPASGS GNVHDSPREQ GQQARSDSSS PPPIEYLPRY
     ER