PALH_ASHGO
ID PALH_ASHGO Reviewed; 502 AA.
AC Q758G4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=pH-response regulator protein palH/RIM21;
GN Name=RIM21; Synonyms=PAL2; OrderedLocusNames=AEL202C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH.
CC {ECO:0000269|PubMed:15001715}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52483.1; -; Genomic_DNA.
DR RefSeq; NP_984659.1; NM_210012.1.
DR AlphaFoldDB; Q758G4; -.
DR STRING; 33169.AAS52483; -.
DR PRIDE; Q758G4; -.
DR EnsemblFungi; AAS52483; AAS52483; AGOS_AEL202C.
DR GeneID; 4620841; -.
DR KEGG; ago:AGOS_AEL202C; -.
DR eggNOG; ENOG502QWMT; Eukaryota.
DR HOGENOM; CLU_026111_0_0_1; -.
DR InParanoid; Q758G4; -.
DR OMA; WEWCNKF; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030437; P:ascospore formation; IEA:EnsemblFungi.
DR GO; GO:0071469; P:cellular response to alkaline pH; IEA:EnsemblFungi.
DR GO; GO:0071467; P:cellular response to pH; IBA:GO_Central.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IEA:EnsemblFungi.
DR GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0070613; P:regulation of protein processing; IEA:EnsemblFungi.
DR GO; GO:0044088; P:regulation of vacuole organization; IEA:EnsemblFungi.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..502
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058195"
FT TOPO_DOM 1..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..206
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..502
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 379..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 55880 MW; 22353EF0B5C8924C CRC64;
MVQRTRWRYS AIAHNYNSCR PMELGAGIAV GAWDGVWARA RSAEFVAATD MGDPVYSAFM
RYDDSAPLHA AVAADWATYV AADFNGGPFK YSIFPILYSF TASLVVTMGL TVIVFFNVRT
KPHRGVPKLL RVAAVLACGN LLTFVVRAMM QLGRDHAEGV VPMNHILDML WTDTAFNTVD
ILAVLILQLC QVQTVMRFFT RFQEKRLISL CGILLAVLSQ VLWAIPPYSE AVSNHFMPLD
DDKDMDVLPP FVYLVRIAQA GSYASFVLMH VFAKKKLCVQ SVQMFLLTVL TVVVVVLQPA
FFITDVTNVW IDNLSEIFST TCYMGSTVIV WEWSNRLSIL EARRQAQSIL GRPVYEDEEQ
GYNFARYALK IQTALTSKSD EGDTTSATTF AAPRSARFEG KGGPQSPVYV QEGEQQAVMA
FNKRMGTRAL AHHVLDSIIY YTDKVVVKGL GNLSASLPSK TSSATSVRGR VRKRIGLEGA
NDVFVYRTKD LVFDSDEDIP RT
