PALH_BOTFB
ID PALH_BOTFB Reviewed; 742 AA.
AC Q5V9L7; A6S3X3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=pH-response regulator protein palH/RIM21;
GN Name=palH; ORFNames=BC1G_07501;
OS Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=332648;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15349749; DOI=10.1007/s00294-004-0524-6;
RA Antal Z., Rascle C., Fevre M., Bruel C.;
RT "Single oligonucleotide nested PCR: a rapid method for the isolation of
RT genes and their flanking regions from expressed sequence tags.";
RL Curr. Genet. 46:240-246(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B05.10;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor pacC in response to alkaline ambient pH. Might be a pH sensor
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; AY575014; AAT81149.1; -; Genomic_DNA.
DR EMBL; CH476882; EDN27517.1; -; Genomic_DNA.
DR RefSeq; XP_001553941.1; XM_001553891.1.
DR AlphaFoldDB; Q5V9L7; -.
DR GeneID; 5434496; -.
DR KEGG; bfu:BCIN_08g03640; -.
DR OMA; VYAVRYQ; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..742
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058196"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 385..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..742
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="N -> S (in Ref. 1; AAT81149)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="T -> A (in Ref. 1; AAT81149)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 742 AA; 81191 MW; 75DA00894171FCD5 CRC64;
MDPRQLINNL KPSSTSAATA THPHCTPFTL PSNGVINLGA SEYFTLTTNA IFNPECTGTA
DIVLTGAGTP TSFVDLRDPF YASTIPACYA LAATTVIAYM LVIMLLITPR TFLVQGAVVL
GRRGFTNGPS GSDAGIGIGG RPWLQKVAAL TVAISLTIAT ADTFRVAEQQ YELGLMNASA
LQEEVEGGME LKIIRIISDT FLWLAQAQTL IRLFPRQREK IIIKWTGFAL ISLDVLFSLL
NNFVYNGNSR PRLFTDAVPA LAYLFQLALS LLYCAWVIYY AISKKRYAFY HPKMRNIFLV
AILSLVSVLV PVVFFVLDIS KPTLAAWGDY VRWVGAAAAS VVVWEWVERI EALERDEKKD
GVLGREVFDG DEMLEVTPTS DWTKRFRKDN DDKGGTATGS TWPAMSGLAN RYRSHATNDL
ETGSVPGQRT GRHLLAVRPP LWPTRPQPAA TPINRADTAS AESTAYTVRY HPISEATPPI
ISGDTTLSRS NSEAISISRS ISNEEVDSDK PVVLEQTNQA AAVAAGLHNW QWNSLNPFKH
RVQGPPAEVS LHTAKPPTPF SSHESSNKWD VRARIEGFAA TQAERFREKT RPTVDTDPLP
LTVIPAPSRR RAVATESEES DTDSISPTPD ESSHIEVTTS RRDRPARTTD PYTPDSLNQH
SITHRGSISF ATAVQPELDQ RVENATASPT LVGSRQTPTF SSSRSSPITV RSPVTPSLPP
IIDGLPVTTI PAPPRRPRVE NP
