ID   PALH_CANGA              Reviewed;         539 AA.
AC   Q6FJT9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=pH-response regulator protein palH/RIM21;
GN   Name=RIM21; OrderedLocusNames=CAGL0M03663g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62481.1; -; Genomic_DNA.
DR   RefSeq; XP_449505.1; XM_449505.1.
DR   AlphaFoldDB; Q6FJT9; -.
DR   STRING; 5478.XP_449505.1; -.
DR   EnsemblFungi; CAG62481; CAG62481; CAGL0M03663g.
DR   GeneID; 2891515; -.
DR   KEGG; cgr:CAGL0M03663g; -.
DR   CGD; CAL0136835; CAGL0M03663g.
DR   VEuPathDB; FungiDB:CAGL0M03663g; -.
DR   eggNOG; ENOG502QWMT; Eukaryota.
DR   HOGENOM; CLU_026111_0_0_1; -.
DR   InParanoid; Q6FJT9; -.
DR   OMA; WEWCNKF; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014844; PalH.
DR   PANTHER; PTHR35779; PTHR35779; 1.
DR   Pfam; PF08733; PalH; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..539
FT                   /note="pH-response regulator protein palH/RIM21"
FT                   /id="PRO_0000058198"
FT   TOPO_DOM        1..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..248
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..310
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        332..539
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  61219 MW;  AD981622A39541BF CRC64;
     MAVSIYDSLR TPGPKHYKYK ICDGIDLGDG LVIDPLNLDS LVVYAKNVKW SSFCDYGVPL
     YLAADTMDTP YEYPPIIMND WRWFIFNDHY FGKYWGYGLY TILMVYSTIF VITVALTVLS
     FLTVNKGPYK ITSLLLKLSS VLASTSIIYF LTSALSTISR QQEHYGVANG NVFGTLLNSN
     LVIATLNLLS MFFYKLCQVS IVARLFERKL EWRIVVFVGG IMSIVSFIIS AIVSYTDRVG
     IRNDNLVTLS PFGLLFDIAL ETCFAFIIVT NVWGTRKTWV SHLQMWYLAL LTIAIVLLSP
     AMFLADVGTG LLSAYAATVS PLLYTMSTFV AWEWLERIHI LKKAAQVKSL LGQKIYEDEQ
     EGYNFAYYSV NNESNLDTNS DSHISLYNDM FRNSEQFSNV GSNLSSKESS SLPAQMNSTG
     ISFPTAVNQV EFQKRKSFLD HLTNFTYSRP YKIYKKSKSI IQLRKRNSET VKNERSNEEL
     SIEKVRRRLG LTNERREYVY NTKDIVFASD DDTESECESN NILNESIDSH FPENGAGSV