PALH_DEBHA
ID PALH_DEBHA Reviewed; 537 AA.
AC Q6BPR6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=pH-response regulator protein palH/RIM21;
GN Name=RIM21; OrderedLocusNames=DEHA2E11396g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; CR382137; CAG88043.2; -; Genomic_DNA.
DR RefSeq; XP_459804.2; XM_459804.1.
DR AlphaFoldDB; Q6BPR6; -.
DR STRING; 4959.XP_459804.2; -.
DR EnsemblFungi; CAG88043; CAG88043; DEHA2E11396g.
DR GeneID; 2902340; -.
DR KEGG; dha:DEHA2E11396g; -.
DR VEuPathDB; FungiDB:DEHA2E11396g; -.
DR eggNOG; ENOG502QWMT; Eukaryota.
DR HOGENOM; CLU_026111_0_0_1; -.
DR InParanoid; Q6BPR6; -.
DR OMA; MELCANA; -.
DR OrthoDB; 1082905at2759; -.
DR Proteomes; UP000000599; Chromosome E.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..537
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058199"
FT TOPO_DOM 1..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..537
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 362..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..378
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 61588 MW; 099D94119B8B3380 CRC64;
MYWRSDEWQE EIYPACEQLS LPEGLLISQN TSFGSQFISR SIFQQKCYKH SVPMLNTNNG
LMLNKFAGLL PIAEQTWHDF TGNSSKGSFA YSVVPVLYSI SISAVITWFL NIFVITNYTI
KPSILLRAST TLSSIYLLIT VIMAIIELHK QQKQGFLHGT KLFDCINSSL ALNIIDLIVV
FLLQINQVQI IMRIFSRQKD KRLTFFVGIF ASITSQVLWA ITRFHSFSDD SEAGDILPAF
QYLVRIAMGV CYAALVSVFV LMKINYIIAN KKIWLITLLT VILIYGPVAF FIADVSNAWV
FELSEIFSVV TYDICVVIPW EWCNKYNSIM KAKEKEGVLG RKFYEDELYE LDRFELFVDE
EDEDHENNNN ENDDESGNEN DNERGNNDHN NRHGLSRNGE NTHKGYRPVN FDGNDKGFGS
IFETYRRTKE TFLNITDHVI AKGLAIPRSA SVFTGTPVSA HNDEVFRMDN LNHKRDDPAD
MTLENQEDHR NTNRNNTIRF ASNSDIHRTN NSTAQNRRDV FVYSTREVII DASDTET
