PALH_EMENI
ID PALH_EMENI Reviewed; 760 AA.
AC Q9P904; C8V2R4; Q5AXU4;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=pH-response regulator protein palH/RIM21;
GN Name=palH; ORFNames=AN6886;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10476033; DOI=10.1046/j.1365-2958.1999.01540.x;
RA Negrete-Urtasun S., Reiter W., Diez E., Denison S.H., Tilburn J.,
RA Espeso E.A., Penalva M.A., Arst H.N. Jr.;
RT "Ambient pH signal transduction in Aspergillus: completion of gene
RT characterization.";
RL Mol. Microbiol. 33:994-1003(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [4]
RP FUNCTION.
RX PubMed=7830727; DOI=10.1007/bf00297286;
RA Arst H.N. Jr., Bignell E., Tilburn J.;
RT "Two new genes involved in signalling ambient pH in Aspergillus nidulans.";
RL Mol. Gen. Genet. 245:787-790(1994).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor pacC in response to alkaline ambient pH. Might be a pH sensor.
CC {ECO:0000269|PubMed:7830727}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; AF152926; AAF70858.1; -; Genomic_DNA.
DR EMBL; AACD01000113; EAA58285.1; -; Genomic_DNA.
DR EMBL; BN001301; CBF71663.1; -; Genomic_DNA.
DR RefSeq; XP_664490.1; XM_659398.1.
DR AlphaFoldDB; Q9P904; -.
DR STRING; 162425.CADANIAP00007687; -.
DR TCDB; 9.B.213.1.2; the 7 tms ph sensor rim21/palh (rim21/palh) family.
DR EnsemblFungi; CBF71663; CBF71663; ANIA_06886.
DR EnsemblFungi; EAA58285; EAA58285; AN6886.2.
DR GeneID; 2870585; -.
DR KEGG; ani:AN6886.2; -.
DR VEuPathDB; FungiDB:AN6886; -.
DR eggNOG; ENOG502QWMT; Eukaryota.
DR HOGENOM; CLU_014594_1_0_1; -.
DR InParanoid; Q9P904; -.
DR OMA; REQSPQI; -.
DR OrthoDB; 588615at2759; -.
DR Proteomes; UP000000560; Chromosome I.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:AspGD.
DR GO; GO:0071467; P:cellular response to pH; IMP:AspGD.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..760
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058200"
FT TOPO_DOM 1..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..328
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 350..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 389..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 83657 MW; 543A34080E8BE726 CRC64;
MEDDGRLAPR QIWARPTSTT TRSYVPGCTP FLLPSDGYVY LNRTYSISLG ENAIYDPACT
STPTTTEHAG AALDIHDPFY ASVTPLLYAM GCATVVSYLL VIILLITPRT FYVGGPGGGA
NFLGRHGMVS GSYSNNSSVV GVGGRPWLQK VAALLVAISL TIATADSFRV AEKQYDHGYS
DAEALTSEVI DGTEIKVVRI ISSTFLWLAQ VQTLIRLFPR HKEKVMIKWA GFALIVLDTI
FAILDKFLVK TNTTRPRLYE DAIPALSYLF ELALNLLYAA WVIFYSLSKH RFAFFHPKMR
NICLVALLSL CAVLIPVVFF VLDIAKPEIA GWGTYIRWVG SAAASVVVWE WVERIEALER
DERKDGILGR EVFDGDEMIE VTPSEEVDWP RQQFHGHDRG GGTGMSSAWG GVMGLAHRPL
RPRGGRITQT QREAEGATAA KSRKRRSARP TPPPAAVTPV SRADTTSAAS TVYNVHYYPV
SSPTPPVAMP FMEEEDEGSD GDGEKELAVV QNQQSSLPTQ DTYTEPRRQN SPQIVNVDNR
WRFILNPFKN RHAALPREVA SAQAEEEGFL SPDDQAPRQG DEENPHYTPR HRGLFSFHPM
SDGASRRQSG ADQPLPVTVI PARRRGQDTW SPQWFTNSNL VDRSSSRRTA SRPRDQRMKV
IQPQVQSAAP WTAADMEASF SSMDYELRYD PEAAALVSED IPDHHSQPTQ ADSPAHPTMS
GGNGPSGGET QSALDTGPGI EGSVNEGSVI EGPEESHSQR
