PALH_KLULA
ID PALH_KLULA Reviewed; 519 AA.
AC Q6CXK7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=pH-response regulator protein palH/RIM21;
GN Name=RIM21; OrderedLocusNames=KLLA0A07469g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; CR382121; CAH02920.1; -; Genomic_DNA.
DR RefSeq; XP_451332.1; XM_451332.1.
DR AlphaFoldDB; Q6CXK7; -.
DR STRING; 28985.XP_451332.1; -.
DR EnsemblFungi; CAH02920; CAH02920; KLLA0_A07469g.
DR GeneID; 2896424; -.
DR KEGG; kla:KLLA0_A07469g; -.
DR eggNOG; ENOG502QWMT; Eukaryota.
DR HOGENOM; CLU_026111_0_0_1; -.
DR InParanoid; Q6CXK7; -.
DR OMA; WEWCNKF; -.
DR Proteomes; UP000000598; Chromosome A.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030437; P:ascospore formation; IEA:EnsemblFungi.
DR GO; GO:0071469; P:cellular response to alkaline pH; IEA:EnsemblFungi.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IEA:EnsemblFungi.
DR GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0070613; P:regulation of protein processing; IEA:EnsemblFungi.
DR GO; GO:0044088; P:regulation of vacuole organization; IEA:EnsemblFungi.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..519
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058201"
FT TOPO_DOM 1..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..279
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..519
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 519 AA; 59667 MW; DD3F3497A20A7243 CRC64;
MTGRSRWRYH FPSEDYSSCQ GVQLDEGVLI WNKLPDKFAY IKSLVFTSNC QDGTPLYSSF
VELEDECPYL PIVAFDWNSY INNDGYTGPF KYSIYSVIYS VTANFIITVF LTVIVFINVP
TKPSRKASYI LKLGALLASL NLSIFVIRVW KNIAENYTYN GYVSSTSFLN LLWGDKVFAG
IDLVVVFLLQ ISQVQIVMRF FDRMQEKRMV FYFGLFLILV TQILWVIPTL SPVPTKDSDS
DIDILPPFVY LFRIALSTCY ASVICFHVLT KKSLCFRGRM IFLTLLTIFT VFLHPTFFIV
DVSNLWIDDL SEIFNTTCYL ASTVIVLEWT NRIHTMERKI HAASVLGRPI YEDEEQNFHF
AIYALRMQNA MKMHRDGHVH DHGHTCDSND NANVSLQNAN TNDSSSIITD NSSQRTSTFG
TMATDQVTLH TQQGERNITQ FKRAETFWNK CHHVLESIVY YTDNVMVNAL AGSKTFDSFT
NDAEKLLKTE RLRKTVGLDE PEDVYLYRKT TMSSDSVME
