PALH_YEAST
ID PALH_YEAST Reviewed; 533 AA.
AC P48565; D6W0P9;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=pH-response regulator protein palH/RIM21;
DE AltName: Full=Regulator of IME2 protein 21;
GN Name=RIM21; Synonyms=PAL2; OrderedLocusNames=YNL294C; ORFNames=N0466;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8553702; DOI=10.1002/yea.320111311;
RA Maurer K.C.T., Urbanus J.H.M., Planta R.J.;
RT "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV
RT carrying a ribosomal protein gene cluster, the genes encoding a plasma
RT membrane protein and a subunit of replication factor C, and a novel
RT putative serine/threonine protein kinase gene.";
RL Yeast 11:1303-1310(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION.
RX PubMed=10821185; DOI=10.1007/s004380051195;
RA Treton B., Blanchin-Roland S., Lambert M., Lepingle A., Gaillardin C.;
RT "Ambient pH signalling in ascomycetous yeasts involves homologues of the
RT Aspergillus nidulans genes palF and palH.";
RL Mol. Gen. Genet. 263:505-513(2000).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH (By similarity).
CC Required for growth at alkaline pH. {ECO:0000250,
CC ECO:0000269|PubMed:10821185}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the palH/RIM21 family. {ECO:0000305}.
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DR EMBL; U23084; AAC49105.1; -; Genomic_DNA.
DR EMBL; Z71570; CAA96212.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10265.1; -; Genomic_DNA.
DR PIR; S63270; S63270.
DR RefSeq; NP_014105.1; NM_001183132.1.
DR AlphaFoldDB; P48565; -.
DR BioGRID; 35543; 398.
DR MINT; P48565; -.
DR STRING; 4932.YNL294C; -.
DR TCDB; 9.B.213.1.1; the 7 tms ph sensor rim21/palh (rim21/palh) family.
DR iPTMnet; P48565; -.
DR PaxDb; P48565; -.
DR PRIDE; P48565; -.
DR EnsemblFungi; YNL294C_mRNA; YNL294C; YNL294C.
DR GeneID; 855422; -.
DR KEGG; sce:YNL294C; -.
DR SGD; S000005238; RIM21.
DR VEuPathDB; FungiDB:YNL294C; -.
DR eggNOG; ENOG502QWMT; Eukaryota.
DR HOGENOM; CLU_026111_0_0_1; -.
DR InParanoid; P48565; -.
DR OMA; WEWCNKF; -.
DR BioCyc; YEAST:G3O-33283-MON; -.
DR PRO; PR:P48565; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P48565; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0030437; P:ascospore formation; IMP:SGD.
DR GO; GO:0071469; P:cellular response to alkaline pH; IMP:SGD.
DR GO; GO:0071467; P:cellular response to pH; IBA:GO_Central.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IMP:SGD.
DR GO; GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
DR GO; GO:0072659; P:protein localization to plasma membrane; IMP:SGD.
DR GO; GO:0070613; P:regulation of protein processing; IMP:SGD.
DR GO; GO:0044088; P:regulation of vacuole organization; IGI:SGD.
DR InterPro; IPR014844; PalH.
DR PANTHER; PTHR35779; PTHR35779; 1.
DR Pfam; PF08733; PalH; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..533
FT /note="pH-response regulator protein palH/RIM21"
FT /id="PRO_0000058205"
FT TOPO_DOM 1..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..533
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..514
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
SQ SEQUENCE 533 AA; 61532 MW; 9492A18512F399CC CRC64;
MNLWRHSPEE LAAYNSCHPM KLGSGVLIQL PLYDNSAVYA EDITFRSFCC ERVPVYVSTV
LRNSSPYRYL DEVINDWQKF IQVSDYVGGS AEYAIYAVIL SITSNFVITV FLTVICCINI
SGRAYKRILQ LLRIASLLAS LNLTIFITKV LRRLEKEHNV YGVVRAHSIM HIFSDDMTFV
VLDFLATLMF QFCQVGIVIR LFQRAQEKRI IFFIGVILTI TANILWVIPP FANHTTKHRN
DWQILRPFVY LFRIAIATSY ASIVIYHIWQ KKKLWFKFNQ MGLLTLLTIL VVLLLPGFFL
ADVSNLWISE LGEVFNTTCY VTSTVITWEW LDRLNVLERK EEAQSILGRP IFEEEQQDYR
FAKYALRVQN ALTRRESQDA STDRHDTSSN SEVCDLQTIS RYDPEDQISV GRSIDRMHFN
DRGTYKDVAL KKLGYARDKI LYFTDQIVQK SVGHNNSSSS KNEKTKQRKA MVRKRLGLDK
PGIYIYSTKD VVFNSDEDDD ENAEDEDDDE YEVGSEGNNN SSATFTSDHI GHI