ID   PALI_CANAL              Reviewed;         346 AA.
AC   Q59WV0; A0A1D8PPI0; Q59XQ5;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 3.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=pH-response regulator protein palI/RIM9;
GN   Name=RIM9; OrderedLocusNames=CAALFM_C600990WA;
GN   ORFNames=CaO19.101, CaO19.7748;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC       factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017628; AOW30045.1; -; Genomic_DNA.
DR   RefSeq; XP_714310.2; XM_709217.2.
DR   AlphaFoldDB; Q59WV0; -.
DR   STRING; 237561.Q59WV0; -.
DR   PRIDE; Q59WV0; -.
DR   GeneID; 3644047; -.
DR   KEGG; cal:CAALFM_C600990WA; -.
DR   CGD; CAL0000199348; RIM9.
DR   VEuPathDB; FungiDB:C6_00990W_A; -.
DR   HOGENOM; CLU_828994_0_0_1; -.
DR   InParanoid; Q59WV0; -.
DR   OrthoDB; 1276221at2759; -.
DR   PRO; PR:Q59WV0; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0071469; P:cellular response to alkaline pH; IMP:CGD.
DR   GO; GO:0071285; P:cellular response to lithium ion; IMP:CGD.
DR   GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
DR   GO; GO:0071467; P:cellular response to pH; IMP:CGD.
DR   GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR   GO; GO:0036177; P:filamentous growth of a population of unicellular organisms in response to pH; IMP:CGD.
DR   GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR   InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR   Pfam; PF06687; SUR7; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..346
FT                   /note="pH-response regulator protein palI/RIM9"
FT                   /id="PRO_0000058209"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..190
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..346
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  39530 MW;  97B3E274F5A224A7 CRC64;
     MFKAFIALLI LLIVCWVIQL LPVIAVPFTT PDANIYLSYY NNYKFGVFGI CNVERHICSK
     PSIGYPSTNS TFYAYDNDES FGTGGIVLPS DVRYTISKLL VVHVVAFCFS SLLLIVIFGL
     IIILFFKYIK TKKDLEGIQL NDSSHEITIH SDEEDNNNNN IDNTNHNNKR ASVTINKTIF
     DLTPFLNLML VFTFFSVLTT LLAFLADILL FTPNLSYLGW LQLIPIVSMA LVTSMLCFIK
     RSISSRKFFE SEYRYANDDM RIMRKTYVDE FWNDNASDDG FYVYTDGFYT RNGDNVQQPT
     SNTAGSLLSE HHDVSIVEPR TFLDTDDSRR GSSPHEFIEL QNLRPV