PALI_DEBHA
ID PALI_DEBHA Reviewed; 365 AA.
AC Q6BNJ2;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=pH-response regulator protein palI/RIM9;
GN Name=RIM9; OrderedLocusNames=DEHA2E21252g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
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DR EMBL; CR382137; CAG88501.2; -; Genomic_DNA.
DR RefSeq; XP_460228.2; XM_460228.1.
DR AlphaFoldDB; Q6BNJ2; -.
DR STRING; 4959.XP_460228.2; -.
DR EnsemblFungi; CAG88501; CAG88501; DEHA2E21252g.
DR GeneID; 2902881; -.
DR KEGG; dha:DEHA2E21252g; -.
DR VEuPathDB; FungiDB:DEHA2E21252g; -.
DR eggNOG; ENOG502S1J0; Eukaryota.
DR HOGENOM; CLU_828994_0_0_1; -.
DR InParanoid; Q6BNJ2; -.
DR OMA; HVVAFCF; -.
DR OrthoDB; 1276221at2759; -.
DR Proteomes; UP000000599; Chromosome E.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..365
FT /note="pH-response regulator protein palI/RIM9"
FT /id="PRO_0000058211"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 154..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 41338 MW; 5DD39BF9329B2D83 CRC64;
MHKGLLILDL FVSICLTIQL LPIISVPITG KGIGYNLHLS KYGNYTFGVL GLCTSNNICS
KPKVGYPPET DAFYSFMDDE NGEYPDFAAA ELPSRARYVI SKLLVVHIVG FCFTTLLFLL
SLALTVILWL EESETKVPFK DAVRKKVKIR QNSRNNSSTE LTESTSATKM NSLSDEGTVD
NERKSKDITP YLNFMLMLSL LSFLSTLLAF LSDILLFIPH LSYLGWLQLC PIILLSTVTS
MLCFIKRSIS SRKYLNDEYR YENDDMRKSV NVGVLNWKDT DSDDGFYVYT NGFYSNYNND
DTPQEGHSHA PELFPANIST HSGWIRHSGH NETGDDVSIS SSRDDSYNEH ENIQMRLLND
HEHIT
