PALI_EMENI
ID PALI_EMENI Reviewed; 549 AA.
AC O93956; C8VA65; Q5B3M7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=pH-response regulator protein palI/RIM9;
GN Name=palI; ORFNames=AN4853;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF GLY-47.
RX PubMed=9791171; DOI=10.1046/j.1365-2958.1998.01058.x;
RA Denison S.H., Negrete-Urtasun S., Mingot J.-M., Tilburn J., Mayer W.A.,
RA Goel A., Espeso E.A., Penalva M.A., Arst H.N. Jr.;
RT "Putative membrane components of signal transduction pathways for ambient
RT pH regulation in Aspergillus and meiosis in Saccharomyces are homologous.";
RL Mol. Microbiol. 30:259-264(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [4]
RP FUNCTION.
RX PubMed=7830727; DOI=10.1007/bf00297286;
RA Arst H.N. Jr., Bignell E., Tilburn J.;
RT "Two new genes involved in signalling ambient pH in Aspergillus nidulans.";
RL Mol. Gen. Genet. 245:787-790(1994).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor pacC in response to alkaline ambient pH. Might be a pH sensor.
CC {ECO:0000269|PubMed:7830727}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF76625.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA60088.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ007629; CAA07588.2; -; mRNA.
DR EMBL; AACD01000083; EAA60088.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001303; CBF76625.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_662457.1; XM_657365.1.
DR AlphaFoldDB; O93956; -.
DR STRING; 162425.CADANIAP00005555; -.
DR EnsemblFungi; EAA60088; EAA60088; AN4853.2.
DR GeneID; 2872654; -.
DR KEGG; ani:AN4853.2; -.
DR VEuPathDB; FungiDB:AN4853; -.
DR eggNOG; ENOG502S1J0; Eukaryota.
DR HOGENOM; CLU_016694_1_0_1; -.
DR InParanoid; O93956; -.
DR OrthoDB; 1276221at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0030428; C:cell septum; IDA:AspGD.
DR GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:AspGD.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..549
FT /note="pH-response regulator protein palI/RIM9"
FT /id="PRO_0000058212"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..549
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 226..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..316
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 47
FT /note="G->D: In palI30; largely prevents proteolytic
FT cleavage of pacC."
FT /evidence="ECO:0000269|PubMed:9791171"
SQ SEQUENCE 549 AA; 58855 MW; 582F05D20016F89D CRC64;
MLLKPATPLT ILLLIAFVLL LLSVISTPIV KSIPLATFDN VEYGVFGYCK AGTCTAIHIG
YTTEEIENTG STDSDFNLPS DARRSLSSIL IVHPIAAFLT LICLCLAAAA HLHAPSHSPR
YLLALLILLL PTLLVSLLAF LVDILLFVPH LSWGGWIVLA ATIILVTCGV VTCAMRRTLV
SRKARKRRIA ENAEMSGQNY YNRQNAAAAA LNESKPIAPE AKETFVAATQ SSESGPTFAT
FRTNTRSSDD DRTPLNNHSD PSAQDAGYQS RIPGDPVPYN APRDDFGNPL PPGAYNSAPR
MRTPGPPGPP PPDSRVRDQY SDPRRGPPTG FAPRGRGGYP PRGGYGRGGP YGGPYGPNSR
APLTGRGGYM GPMRGGPAGP MARGGYRPQP AAGGYGNARA MGEDEYGYRG PSSRQRTPGP
MAAPAAPGPA GQAIEMMPQP RHEPDAQDEV PEQQQLHAIS IDNQHEPVSP TSLYSRTQSY
VPPRRNWGPQ AYQSSEPNLP YQPNQPRHAR SQSGSMYYED EDPVYTSRNE SAVGNSGVPS
VLTPGNSAK
