PALI_NEUCR
ID PALI_NEUCR Reviewed; 700 AA.
AC Q7SFN5;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=pH-response regulator protein palI/prr-5;
DE AltName: Full=pH-response regulator 5;
GN Name=prr-5; Synonyms=rim9; ORFNames=B13D15.020, NCU01996;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor pacc-1 in response to alkaline ambient pH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE76357.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX842630; CAE76357.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM002236; EAA35625.2; -; Genomic_DNA.
DR RefSeq; XP_964861.2; XM_959768.2.
DR AlphaFoldDB; Q7SFN5; -.
DR STRING; 5141.EFNCRP00000001213; -.
DR EnsemblFungi; EAA35625; EAA35625; NCU01996.
DR GeneID; 3881001; -.
DR KEGG; ncr:NCU01996; -.
DR VEuPathDB; FungiDB:NCU01996; -.
DR HOGENOM; CLU_016694_1_0_1; -.
DR InParanoid; Q7SFN5; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..700
FT /note="pH-response regulator protein palI/prr-5"
FT /id="PRO_0000058214"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..700
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 226..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 73563 MW; 10DCE4428D630CEE CRC64;
MLRPATPLAV LLFAAFGLLT LATISTPIIK QIPLSSFEIK DVGDLSFGVF GYCTSSGCSP
IEIGYDTSAF SDKINSDFDI PRATRSTLSS ILIVHPVAAL ITLINFVLAI VAHFHSPSHS
ARYLLILFIV SFVDFIVCLL CFLVDVLLFI PHLSWGSYIV VAATILVAFC GLVTCAMRRT
LVNRKANRKR IAENAEMSGE NYYNRQAQTA PVTQVTGPQP TVPMISGANG GGDKLPEFTT
FEKKDDRSEE RIPLTSVSPI ERSPATLVND STPPNFMDGA PSRSPSTTPV GRDQYGNPLP
PQDGYAMRVG PQNERLNSRG RGGMPPGGYR GRGGFPGPGR GGGPPQNGRG GYGPPGRGRG
GYGPPPRGYG GPGPRGGRGP PPQGYQGGPD RRPSPGAPYG PGPGVGTYGP SQPSPYANRQ
QSPGPQFAAP GYGNPEQPGP QYSAYNPRRV SLPRAESPPP LPGIDDGMPG PAVELDASPA
NRGVGQYGIR DSDSDVAGML AMQQARVPDP DRGNDANGHS QEGPNDVYVP PRQAWNQGFV
GSTPGLAPPT ARGPTRPISE AVTATVASDY YEDVDPRFAE PSAAADKRPP PISMQSPPAS
NSYDDIPNRA RSPAESENSN FTSISQRGIN PRWNSANAPM PPPVAGVYAG GGGGGNVVPR
RPVNRPGAGP ADGSDLFLNS NPDFQLPGRG GNMPRAAGPR
