PALI_YARLI
ID PALI_YARLI Reviewed; 728 AA.
AC Q7Z8R5; Q6C3M3;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 3.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=pH-response regulator protein palI/RIM9;
GN Name=RIM9; OrderedLocusNames=YALI0E33627g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SY12;
RA Gonzalez-Lopez C.I., Blanchin-Roland S., Gaillardin C., Ruiz-Herrera J.;
RT "Isolation and molecular analysis of YLRIM9/PALI, a gene encoding a
RT putative transmembranal protein involved in the RIM pathway from Yarrowia
RT lipolytica.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [3]
RP FUNCTION.
RX PubMed=11861549; DOI=10.1093/genetics/160.2.417;
RA Gonzalez-Lopez C.I., Szabo R., Blanchin-Roland S., Gaillardin C.;
RT "Genetic control of extracellular protease synthesis in the yeast Yarrowia
RT lipolytica.";
RL Genetics 160:417-427(2002).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcription
CC factor RIM101 in response to alkaline ambient pH.
CC {ECO:0000269|PubMed:11861549}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AJ566902; CAD98727.2; -; Genomic_DNA.
DR EMBL; CR382131; CAG80343.1; -; Genomic_DNA.
DR RefSeq; XP_504739.1; XM_504739.1.
DR AlphaFoldDB; Q7Z8R5; -.
DR GeneID; 2911587; -.
DR KEGG; yli:YALI0E33627g; -.
DR InParanoid; Q7Z8R5; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..728
FT /note="pH-response regulator protein palI/RIM9"
FT /id="PRO_0000058215"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..153
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..728
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 268..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..333
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..641
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 14
FT /note="I -> N (in Ref. 1; CAD98727)"
FT /evidence="ECO:0000305"
FT CONFLICT 694
FT /note="S -> F (in Ref. 1; CAD98727)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 728 AA; 77678 MW; 3CF158BADE447A6E CRC64;
MGLRMKSATG LLVILLIAFA LQLVAVLSVP VTKTISLGSY QDHKFGVFGY CNVKDGTCSP
AGVGYNLVDS DNAGFSLPSN ARHTLSNLLI VHPIATGFTL ILTVLAMLAH IQGPASSSRY
LLFCLVFSLP TFLLVLLSFL VDILLFVPHL DWGGWIVLAA TILVAISGVV LCVMRRTLSS
KKAMKKHQLD TTNELSAFSS HKHLNSFTYS SKENVPQFSE LRYETSHDTS KDEEVLPLTS
HVYEEPGHHV GDTSYASQGT NNSRVNLLTS EEPQAPKRES PFKDQRQDRY TPDRYGPSPD
RYDQGGPGRP PNGSRGVPPR RPSNGPTPPG QGPSPTGAYG RNNNPNYNGG YNNRLPRPRG
PPGSNNSSPF LGARNGPGLT PPHNLQTATT GPMQLPAGTY LPGEEPANSP DTYGPGVIPI
PEIRRESKVP GASPTPPPVS GNSPPTETSE SGVSRPYRGN YSRRGSEASA QTPPNAQPNP
PPGGAQNYEY VPARQQWNLT TEESNATAPA PGPQPLQRNH SYDTYNPYRS ETPSAPGSRA
QSQGTDDNLG TLHQPVPTTV TPSNSGALNN KDSPWYSPPV DEQFRNSFIP DAPVSPSESI
SSNFTSVSQR GINPRYFGAD GPPGGLHQGA PPPPHMRGPP PHMGMGGPNM GGHNMGGHNM
GGPPPNMGPR PPYGGGGPGH GNKHDLLLSG NPDSQFQPQT RRKPGRGGRP GMSPASLMGR
DTGPYSMR
