PALI_YEAST
ID PALI_YEAST Reviewed; 239 AA.
AC Q04734; D6VZN7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=pH-response regulator protein palI/RIM9;
DE AltName: Full=Regulator of IME2 protein 9;
GN Name=RIM9; OrderedLocusNames=YMR063W; ORFNames=YM9916.02;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=9017390; DOI=10.1093/genetics/145.1.63;
RA Li W., Mitchell A.P.;
RT "Proteolytic activation of Rim1p, a positive regulator of yeast sporulation
RT and invasive growth.";
RL Genetics 145:63-73(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-239.
RX PubMed=8358819; DOI=10.1007/bf00324676;
RA Payne M.J., Lukins H.B.;
RT "Characterization of a second nuclear gene, AEP1, required for expression
RT of the mitochondrial OLI1 gene in Saccharomyces cerevisiae.";
RL Curr. Genet. 24:126-135(1993).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Required for the proteolytic cleavage of the transcriptional
CC repressor RIM101 in response to alkaline ambient pH, which is necessary
CC for sporulation and invasive growth. {ECO:0000269|PubMed:9017390}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the palI/RIM9 family. {ECO:0000305}.
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DR EMBL; U86641; AAC49630.1; -; Genomic_DNA.
DR EMBL; Z48952; CAA88788.1; -; Genomic_DNA.
DR EMBL; M80615; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR EMBL; BK006946; DAA09961.1; -; Genomic_DNA.
DR PIR; S52823; S52823.
DR RefSeq; NP_013779.1; NM_001182561.1.
DR AlphaFoldDB; Q04734; -.
DR BioGRID; 35238; 287.
DR DIP; DIP-4447N; -.
DR IntAct; Q04734; 1.
DR STRING; 4932.YMR063W; -.
DR iPTMnet; Q04734; -.
DR PaxDb; Q04734; -.
DR EnsemblFungi; YMR063W_mRNA; YMR063W; YMR063W.
DR GeneID; 855085; -.
DR KEGG; sce:YMR063W; -.
DR SGD; S000004667; RIM9.
DR VEuPathDB; FungiDB:YMR063W; -.
DR eggNOG; ENOG502S1J0; Eukaryota.
DR HOGENOM; CLU_084537_1_0_1; -.
DR InParanoid; Q04734; -.
DR OMA; DWPGWLM; -.
DR BioCyc; YEAST:G3O-32765-MON; -.
DR PRO; PR:Q04734; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q04734; protein.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0030437; P:ascospore formation; IMP:SGD.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..239
FT /note="pH-response regulator protein palI/RIM9"
FT /id="PRO_0000058216"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 239 AA; 26697 MW; 8310BF42D5A27E10 CRC64;
MVSMIHIVVF LLAITTMFEI LPLITVPVTK YLSLSSFRNH YYGLFGWCVR GQNQELMCTK
MKIGYDSTDV DSSGHVLTLP SNSKVVVSNL LVVHPISLAF TGTLLILAVI IMVTPLGDSP
EMLLFTALFS LPTFMLCLLC FLVDILLFIS KLDWPGWLML AATISVALCC SMLWVMRRVV
SVKKYESQQS IAHACSMEQY SISDIYQSKQ NGNSSEYEVA PTHTDSLIAP EVTYRGFIE
