PALM2_HUMAN
ID PALM2_HUMAN Reviewed; 379 AA.
AC Q8IXS6; A9Z1X9; Q8N9D5; Q96DU1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Paralemmin-2;
DE Flags: Precursor;
GN Name=PALM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 3),
RP AND TISSUE SPECIFICITY.
RC TISSUE=Muscle;
RX PubMed=11478809; DOI=10.1006/bbrc.2001.5329;
RA Hu B., Copeland N.G., Gilbert D.J., Jenkins N.A., Kilimann M.W.;
RT "The paralemmin protein family: identification of paralemmin-2, an isoform
RT differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant
RT cytosolic relative.";
RL Biochem. Biophys. Res. Commun. 285:1369-1376(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q8IXS6; Q96CV9: OPTN; NbExp=3; IntAct=EBI-12871462, EBI-748974;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8IXS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IXS6-2; Sequence=VSP_022566, VSP_022567;
CC Name=3; Synonyms=PALM2-AKAP2;
CC IsoId=Q9Y2D5-4; Sequence=External;
CC Name=4;
CC IsoId=Q9Y2D5-6; Sequence=External;
CC -!- TISSUE SPECIFICITY: Expressed in infantile heart and muscle, and
CC fibroblasts. {ECO:0000269|PubMed:11478809}.
CC -!- SIMILARITY: Belongs to the paralemmin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39306.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ312216; CAC59693.1; -; mRNA.
DR EMBL; AK095003; BAC04472.1; -; mRNA.
DR EMBL; AL135789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL158829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039306; AAH39306.2; ALT_INIT; mRNA.
DR CCDS; CCDS35099.1; -. [Q8IXS6-1]
DR CCDS; CCDS48002.2; -. [Q8IXS6-2]
DR RefSeq; NP_001032370.1; NM_001037293.2. [Q8IXS6-1]
DR RefSeq; NP_443749.5; NM_053016.5. [Q8IXS6-2]
DR AlphaFoldDB; Q8IXS6; -.
DR SMR; Q8IXS6; -.
DR BioGRID; 125312; 64.
DR IntAct; Q8IXS6; 13.
DR MINT; Q8IXS6; -.
DR STRING; 9606.ENSP00000323805; -.
DR iPTMnet; Q8IXS6; -.
DR PhosphoSitePlus; Q8IXS6; -.
DR SwissPalm; Q8IXS6; -.
DR BioMuta; PALM2; -.
DR DMDM; 124015203; -.
DR EPD; Q8IXS6; -.
DR jPOST; Q8IXS6; -.
DR MassIVE; Q8IXS6; -.
DR MaxQB; Q8IXS6; -.
DR PeptideAtlas; Q8IXS6; -.
DR PRIDE; Q8IXS6; -.
DR ProteomicsDB; 71057; -. [Q8IXS6-1]
DR ProteomicsDB; 71058; -. [Q8IXS6-2]
DR Antibodypedia; 56405; 50 antibodies from 16 providers.
DR DNASU; 445815; -.
DR GeneID; 445815; -.
DR KEGG; hsa:445815; -.
DR UCSC; uc004beg.4; human. [Q8IXS6-1]
DR CTD; 445815; -.
DR DisGeNET; 445815; -.
DR GeneCards; PALM2; -.
DR HGNC; HGNC:15845; PALM2.
DR HPA; ENSG00000157654; Low tissue specificity.
DR neXtProt; NX_Q8IXS6; -.
DR OpenTargets; ENSG00000157654; -.
DR PharmGKB; PA32924; -.
DR VEuPathDB; HostDB:ENSG00000157654; -.
DR eggNOG; ENOG502QSC7; Eukaryota.
DR GeneTree; ENSGT00930000151059; -.
DR InParanoid; Q8IXS6; -.
DR OrthoDB; 275462at2759; -.
DR PhylomeDB; Q8IXS6; -.
DR TreeFam; TF105402; -.
DR PathwayCommons; Q8IXS6; -.
DR SignaLink; Q8IXS6; -.
DR BioGRID-ORCS; 114299; 13 hits in 1041 CRISPR screens.
DR ChiTaRS; PALM2; human.
DR GenomeRNAi; 114299; -.
DR Pharos; Q8IXS6; Tbio.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8IXS6; protein.
DR ExpressionAtlas; Q8IXS6; baseline and differential.
DR Genevisible; Q8IXS6; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR InterPro; IPR004965; Paralemmin.
DR Pfam; PF03285; Paralemmin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Coiled coil; Lipoprotein; Membrane;
KW Methylation; Palmitate; Phosphoprotein; Prenylation; Reference proteome.
FT CHAIN 1..376
FT /note="Paralemmin-2"
FT /id="PRO_0000273446"
FT PROPEP 377..379
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000396693"
FT REGION 246..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2..37
FT /evidence="ECO:0000255"
FT COILED 69..110
FT /evidence="ECO:0000255"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BR92"
FT MOD_RES 358
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 376
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 373
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 375
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 376
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..2
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11478809"
FT /id="VSP_022566"
FT VAR_SEQ 133
FT /note="G -> GDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAA (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:11478809"
FT /id="VSP_022567"
FT CONFLICT 63..72
FT /note="Missing (in Ref. 2; BAC04472)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="Q -> R (in Ref. 4; AAH39306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 42185 MW; 5400EDC39ABE7298 CRC64;
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE KWLLQGIPAG
TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE SQISAKEQII LEKLKETEKS
FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE TKILSTSTIG PEGVHQKGVK VYDDGTKVVY
EVRSGGTVVE NGVHKLSTKD VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE
AKLEMVHKSR KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY
DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS SPEGKEESLA
TEPAPGTQKK KRCQCCVVM
