PALM2_MOUSE
ID PALM2_MOUSE Reviewed; 376 AA.
AC Q8BR92;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Paralemmin-2;
DE Flags: Precursor;
GN Name=Palm2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paralemmin family. {ECO:0000305}.
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DR EMBL; AK045344; BAC32319.1; -; mRNA.
DR EMBL; BC113156; AAI13157.1; -; mRNA.
DR CCDS; CCDS18202.1; -.
DR RefSeq; NP_766456.1; NM_172868.3.
DR AlphaFoldDB; Q8BR92; -.
DR SMR; Q8BR92; -.
DR STRING; 10090.ENSMUSP00000099968; -.
DR iPTMnet; Q8BR92; -.
DR PhosphoSitePlus; Q8BR92; -.
DR SwissPalm; Q8BR92; -.
DR MaxQB; Q8BR92; -.
DR PaxDb; Q8BR92; -.
DR PeptideAtlas; Q8BR92; -.
DR PRIDE; Q8BR92; -.
DR ProteomicsDB; 294154; -.
DR Ensembl; ENSMUST00000102904; ENSMUSP00000099968; ENSMUSG00000090053.
DR Ensembl; ENSMUST00000102905; ENSMUSP00000099969; ENSMUSG00000090053.
DR GeneID; 677884; -.
DR UCSC; uc008syg.2; mouse.
DR CTD; 677884; -.
DR MGI; MGI:1934601; Palm2.
DR VEuPathDB; HostDB:ENSMUSG00000090053; -.
DR eggNOG; ENOG502QSC7; Eukaryota.
DR GeneTree; ENSGT00940000161837; -.
DR HOGENOM; CLU_038333_1_0_1; -.
DR InParanoid; Q8BR92; -.
DR OMA; HSANPRH; -.
DR PhylomeDB; Q8BR92; -.
DR TreeFam; TF105402; -.
DR BioGRID-ORCS; 242481; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Palm2; mouse.
DR PRO; PR:Q8BR92; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BR92; protein.
DR Bgee; ENSMUSG00000090053; Expressed in dentate gyrus of hippocampal formation granule cell and 96 other tissues.
DR ExpressionAtlas; Q8BR92; baseline and differential.
DR Genevisible; Q8BR92; MM.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR InterPro; IPR004965; Paralemmin.
DR Pfam; PF03285; Paralemmin; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Lipoprotein; Membrane; Methylation; Palmitate;
KW Phosphoprotein; Prenylation; Reference proteome.
FT CHAIN 1..373
FT /note="Paralemmin-2"
FT /id="PRO_0000273447"
FT PROPEP 374..376
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000396694"
FT REGION 243..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..34
FT /evidence="ECO:0000255"
FT COILED 67..108
FT /evidence="ECO:0000255"
FT COMPBIAS 247..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 315
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16452087,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IXS6"
FT MOD_RES 373
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 370
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 372
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 373
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 376 AA; 42095 MW; 8ACC5973898D28F4 CRC64;
MAEAELHKER LQAIAEKRKR QTEIEGKRRQ LDEQVLLLQH SKSKVLREKW LLQGVPAGTA
EEEEARRRQS EEDEFKVKQL EDNIQRLEQE IQALESEESQ ISAKEQIILE KLKETEKSFK
DLQKSFSTAD GAIYAMEINV EKDKQTGETK ILSASTIGPE GVHQRGVKVY DDGTKVVYEV
HSGGTVVENG VHKLSAKDVE ELIQKAGQSS FRRHMSERTV VADGSLGHPK EHMLCKEAKL
EMVQKSRKDQ SSGNPGQQAQ PPITEEPGAN LDQPVTMIFM GYQNIEDEEE TKKVLGYDET
IKAELVLIDE DDEKSLREKT VTDVSTIDGN AAELVSGRPL SDTTEPSSPE GKEESLATDP
APGTQKKKRC QCCVVM