PAM17_ASHGO
ID PAM17_ASHGO Reviewed; 186 AA.
AC Q759E9;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Presequence translocated-associated motor subunit PAM17, mitochondrial;
DE Flags: Precursor;
GN Name=PAM17; OrderedLocusNames=ADR328W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the PAM complex, a complex required for the
CC translocation of transit peptide-containing proteins from the inner
CC membrane into the mitochondrial matrix in an ATP-dependent manner.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the PAM complex, at least composed of mtHsp70
CC (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PAM17 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52248.1; -; Genomic_DNA.
DR RefSeq; NP_984424.1; NM_209777.1.
DR AlphaFoldDB; Q759E9; -.
DR STRING; 33169.AAS52248; -.
DR EnsemblFungi; AAS52248; AAS52248; AGOS_ADR328W.
DR GeneID; 4620590; -.
DR KEGG; ago:AGOS_ADR328W; -.
DR eggNOG; ENOG502S1B1; Eukaryota.
DR HOGENOM; CLU_068297_2_0_1; -.
DR InParanoid; Q759E9; -.
DR OMA; YKPSVNT; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001405; C:PAM complex, Tim23 associated import motor; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR InterPro; IPR013875; Pam17.
DR PANTHER; PTHR28021; PTHR28021; 1.
DR Pfam; PF08566; Pam17; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Transit peptide; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 28..186
FT /note="Presequence translocated-associated motor subunit
FT PAM17, mitochondrial"
FT /id="PRO_0000043149"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 186 AA; 20948 MW; DE48A12982344C3C CRC64;
MLARGILRPA LARAELGRAF SCSAQWQQAA GSTSGRELSW PDFFALRKTE RRINTGSSVL
TAFLTANCAW AYISTVQIDV TQMLFGFDPM VVLVGALFAS SGLGYLCGPL MGSAFFRVKH
RGQLEGYNHK NRVFLEHIKK NRVDASSQSF SNPLPDYYGE KIGSLQEYRQ WLRDCQSHRR
KAKEFL
