ID   PAM17_CRYNJ             Reviewed;         217 AA.
AC   P0CP48; Q55PU1; Q5KDL4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Presequence translocated-associated motor subunit PAM17, mitochondrial;
DE   Flags: Precursor;
GN   Name=PAM17; OrderedLocusNames=CNG03540;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the PAM complex, a complex required for the
CC       translocation of transit peptide-containing proteins from the inner
CC       membrane into the mitochondrial matrix in an ATP-dependent manner.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the PAM complex, at least composed of mtHsp70
CC       (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PAM17 family. {ECO:0000305}.
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DR   EMBL; AE017347; AAW44870.1; -; Genomic_DNA.
DR   RefSeq; XP_572177.1; XM_572177.1.
DR   AlphaFoldDB; P0CP48; -.
DR   STRING; 5207.AAW44870; -.
DR   PaxDb; P0CP48; -.
DR   EnsemblFungi; AAW44870; AAW44870; CNG03540.
DR   GeneID; 3258958; -.
DR   KEGG; cne:CNG03540; -.
DR   VEuPathDB; FungiDB:CNG03540; -.
DR   eggNOG; ENOG502S1B1; Eukaryota.
DR   HOGENOM; CLU_068297_2_0_1; -.
DR   InParanoid; P0CP48; -.
DR   OMA; YKPSVNT; -.
DR   OrthoDB; 1353188at2759; -.
DR   Proteomes; UP000002149; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001405; C:PAM complex, Tim23 associated import motor; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   InterPro; IPR013875; Pam17.
DR   PANTHER; PTHR28021; PTHR28021; 1.
DR   Pfam; PF08566; Pam17; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW   Reference proteome; Transit peptide; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..217
FT                   /note="Presequence translocated-associated motor subunit
FT                   PAM17, mitochondrial"
FT                   /id="PRO_0000043153"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          33..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  24072 MW;  5F6B315ACAAA28E8 CRC64;
     MSRSVFSTLR PVIGQKTTLA PFAFSLRHAS SSSSPFSTPT EPTSFHTQPS HSTPTGPLPL
     TWPSYLSLRR QRRLWSTLTS VPTTFLGLFL GGGYFASLEA DPSQLIFGVE PMFVYGGATL
     GCMALGYLIG PSVGATLFSL THPSIARGNP APLEVMDREF YHRIRKNRAD PRFQSVQNIV
     PDFYGEKIVS LSTYRRWLRD QAVYKRKAMH GVPGEDL