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PAM68_ARATH
ID   PAM68_ARATH             Reviewed;         214 AA.
AC   O49668;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Protein PAM68, chloroplastic;
DE   AltName: Full=PHOTOSYNTHESIS AFFECTED MUTANT 68;
DE   Flags: Precursor;
GN   Name=PAM68; OrderedLocusNames=At4g19100; ORFNames=T18B16.70;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19376835; DOI=10.1104/pp.109.138677;
RA   Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA   Grossmann J., Gruissem W., Baginsky S.;
RT   "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT   chloroplast kinase substrates and phosphorylation networks.";
RL   Plant Physiol. 150:889-903(2009).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH PSBA; PSBB;
RP   PSBC; PSBD; PSBH; PSBI; HCF136; LPA1; LPA2 AND ALB3, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=20923938; DOI=10.1105/tpc.110.077453;
RA   Armbruster U., Zuhlke J., Rengstl B., Kreller R., Makarenko E., Ruhle T.,
RA   Schunemann D., Jahns P., Weisshaar B., Nickelsen J., Leister D.;
RT   "The Arabidopsis thylakoid protein PAM68 is required for efficient D1
RT   biogenesis and photosystem II assembly.";
RL   Plant Cell 22:3439-3460(2010).
CC   -!- FUNCTION: Involved in early steps in photosystem II (PSII) biogenesis
CC       and in maturation and stability of newly synthesized psbA protein.
CC       {ECO:0000269|PubMed:20923938}.
CC   -!- SUBUNIT: Interacts with the PSII subunits psbA, psbB, psbC, psbD, psbH
CC       and psbI, but not with psbE, psbF or psbO. Interacts with the PSII
CC       assembly factors HCF136, LPA1, LPA2 and ALB3.
CC       {ECO:0000269|PubMed:20923938}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC       {ECO:0000269|PubMed:20923938}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:20923938}.
CC   -!- DISRUPTION PHENOTYPE: Strongly reduced growth. Pale-green cotyledons
CC       and leaves. {ECO:0000269|PubMed:20923938}.
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DR   EMBL; BT029521; ABL66777.1; -; mRNA.
DR   EMBL; AL021687; CAA16699.1; -; Genomic_DNA.
DR   EMBL; AL161550; CAB78912.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE84140.1; -; Genomic_DNA.
DR   PIR; T04431; T04431.
DR   RefSeq; NP_974571.1; NM_202842.3.
DR   AlphaFoldDB; O49668; -.
DR   STRING; 3702.AT4G19100.1; -.
DR   iPTMnet; O49668; -.
DR   PaxDb; O49668; -.
DR   PRIDE; O49668; -.
DR   ProteomicsDB; 248634; -.
DR   EnsemblPlants; AT4G19100.1; AT4G19100.1; AT4G19100.
DR   GeneID; 2745715; -.
DR   Gramene; AT4G19100.1; AT4G19100.1; AT4G19100.
DR   KEGG; ath:AT4G19100; -.
DR   Araport; AT4G19100; -.
DR   TAIR; locus:1006589876; AT4G19100.
DR   eggNOG; ENOG502RXKE; Eukaryota.
DR   HOGENOM; CLU_099250_0_0_1; -.
DR   InParanoid; O49668; -.
DR   OrthoDB; 1629732at2759; -.
DR   PhylomeDB; O49668; -.
DR   BioCyc; MetaCyc:MON-16601; -.
DR   PRO; PR:O49668; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O49668; baseline and differential.
DR   Genevisible; O49668; AT.
DR   GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR   GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009523; C:photosystem II; IEA:UniProtKB-KW.
DR   GO; GO:0010207; P:photosystem II assembly; IMP:TAIR.
DR   InterPro; IPR021855; PAM68-like.
DR   PANTHER; PTHR34575; PTHR34575; 1.
DR   Pfam; PF11947; DUF3464; 1.
PE   1: Evidence at protein level;
KW   Chloroplast; Membrane; Photosynthesis; Photosystem II; Plastid;
KW   Reference proteome; Thylakoid; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..35
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..214
FT                   /note="Protein PAM68, chloroplastic"
FT                   /id="PRO_0000403964"
FT   TOPO_DOM        36..124
FT                   /note="Stromal"
FT                   /evidence="ECO:0000269|PubMed:20923938"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..152
FT                   /note="Lumenal, thylakoid"
FT                   /evidence="ECO:0000269|PubMed:20923938"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..214
FT                   /note="Stromal"
FT                   /evidence="ECO:0000269|PubMed:20923938"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..108
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  24212 MW;  7E92404A98CE1F8C CRC64;
     MASVPCSFKL SAHRRSSSKL DGNNKQCSSL VERLRDKTKS QVPKSITCIN RLEISRIAPL
     HATMNSPKGF GPPPKKTKKS KKPKPGNQSD EDDDDEDEDD DDEEDERERG VIPEIVTNRM
     ISRMGFTVGL PLFIGLLFFP FFYYLKVGLK VDVPTWVPFI VSFVFFGTAL AGVSYGIVSS
     SWDPLREGSL LGWNEAKKNW PVFWQSFWNS SDKR
 
 
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