ID   PAN3L_SCHPO             Reviewed;         681 AA.
AC   O13865;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=PAB-dependent poly(A)-specific ribonuclease subunit pan3-like;
DE   AltName: Full=PAB1P-dependent poly(A)-nuclease;
GN   ORFNames=SPAC1B1.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Regulatory subunit of the poly(A)-nuclease (PAN)
CC       deadenylation complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. PAN3 family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB11083.2; -; Genomic_DNA.
DR   PIR; T38017; T38017.
DR   RefSeq; NP_594234.2; NM_001019657.2.
DR   AlphaFoldDB; O13865; -.
DR   SMR; O13865; -.
DR   BioGRID; 279009; 3.
DR   STRING; 4896.SPAC1B1.04c.1; -.
DR   iPTMnet; O13865; -.
DR   MaxQB; O13865; -.
DR   PaxDb; O13865; -.
DR   PRIDE; O13865; -.
DR   EnsemblFungi; SPAC1B1.04c.1; SPAC1B1.04c.1:pep; SPAC1B1.04c.
DR   GeneID; 2542552; -.
DR   KEGG; spo:SPAC1B1.04c; -.
DR   PomBase; SPAC1B1.04c; -.
DR   VEuPathDB; FungiDB:SPAC1B1.04c; -.
DR   eggNOG; KOG3741; Eukaryota.
DR   HOGENOM; CLU_403404_0_0_1; -.
DR   InParanoid; O13865; -.
DR   OMA; INTAFME; -.
DR   PRO; PR:O13865; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0031251; C:PAN complex; ISO:PomBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; ISO:PomBase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR030844; PAN3.
DR   InterPro; IPR041332; Pan3_PK.
DR   PANTHER; PTHR12272; PTHR12272; 1.
DR   Pfam; PF18101; Pan3_PK; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Metal-binding; Phosphoprotein; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..681
FT                   /note="PAB-dependent poly(A)-specific ribonuclease subunit
FT                   pan3-like"
FT                   /id="PRO_0000372357"
FT   ZN_FING         9..38
FT                   /note="C3H1-type"
FT   REGION          38..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         165
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   681 AA;  76046 MW;  CFAD3FBE2DDAB2B2 CRC64;
     MDERRSSIFS TNIPCRNEQL YGRCPYIDKG CFFQHKNQDN APASSKPPSA TAIDPQNSGF
     STKLSINSPS FTPLKLSKTS ISSASNKESV PLTRPKSYSS ALSSGKNGAA AQQAANSPKT
     VSLMTSSSKA ANALQTHKSS LARAASAVPF SPSKATTVSL KESASLTSLS NNKSVSNLNS
     ISGASSPSGS LVNLHSLTRS ASFVPQPSVP NSGQLSNADM SRHILARFPP FFHNLNEQQQ
     KTTSFFLADD HLKWFTYLTQ EFYQFANIPK LPSHVLSYHS LIPRRMIVTV LPVLRYATSI
     YKVIDGNNGL PYSFVQLRDF TLLNDRNITN VSPWTKVDSP HVIKIREAFT THAFEQKSIV
     FVYNYLPSCP SLYDLFFASP VFRKRTSSFY FSQPLKATKE VLWCFASQLI SALYSIHSSG
     LAAKMVSLKN VLMVGKMRLA IFGLGIMDVI QEESTEPLTS LQRNDCRDVG LILLALATDT
     ENVTLSTAKA HLTRLKTIVS TDASLVELIE VLIFNEELRI QTLLPTMLSY MVNNYESVLL
     MEDVYETYLA EQVENDRLLR LLLKLEFLDD RPEYVDDPDW SASGVYFVIR LFRKYMFQVQ
     TIDDASKKPT LQSTTTPPRK LLNKAHLLSC LNKLDAGTDE QILLEDEFTR IIMSFKEVKT
     TINTAFMELE RRCSNNLSVK K