A33A_DROME
ID A33A_DROME Reviewed; 47 AA.
AC O46227;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Accessory gland peptide Acp33A;
DE Flags: Precursor;
GN Name=Acp33A; ORFNames=CG6555;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAG32771.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Male accessory gland;
RX PubMed=9474779; DOI=10.1016/s0965-1748(97)00056-8;
RA Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W.,
RA Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.;
RT "New genes for male accessory gland proteins in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 27:825-834(1997).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-47.
RC STRAIN=WS1, WS16, WS17, WS19, WS26, WS47, WS49, WS9, ZIM10C, ZIM22C,
RC ZIM24C, ZIM30C, ZIM32C, ZIM35C, ZIM49C, ZIM5C, and ZIM7C;
RX PubMed=11102381; DOI=10.1093/genetics/156.4.1879;
RA Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G.;
RT "Molecular population genetics of male accessory gland proteins in
RT Drosophila.";
RL Genetics 156:1879-1888(2000).
CC -!- FUNCTION: Responsible for physiological and behavioral changes in mated
CC female flies. {ECO:0000269|PubMed:9474779}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Main cells of accessory gland and seminal fluid.
CC {ECO:0000269|PubMed:9474779}.
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DR EMBL; U90950; AAB96397.1; -; mRNA.
DR EMBL; AE014134; AAF53108.2; -; Genomic_DNA.
DR EMBL; AY010560; AAG32771.1; -; Genomic_DNA.
DR EMBL; AY010561; AAG32772.1; -; Genomic_DNA.
DR EMBL; AY010562; AAG32773.1; -; Genomic_DNA.
DR EMBL; AY010563; AAG32774.1; -; Genomic_DNA.
DR EMBL; AY010564; AAG32775.1; -; Genomic_DNA.
DR EMBL; AY010565; AAG32776.1; -; Genomic_DNA.
DR EMBL; AY010566; AAG32777.1; -; Genomic_DNA.
DR EMBL; AY010567; AAG32778.1; -; Genomic_DNA.
DR EMBL; AY010568; AAG32779.1; -; Genomic_DNA.
DR EMBL; AY010569; AAG32780.1; -; Genomic_DNA.
DR EMBL; AY010570; AAG32781.1; -; Genomic_DNA.
DR EMBL; AY010571; AAG32782.1; -; Genomic_DNA.
DR EMBL; AY010572; AAG32783.1; -; Genomic_DNA.
DR EMBL; AY010573; AAG32784.1; -; Genomic_DNA.
DR EMBL; AY010574; AAG32785.1; -; Genomic_DNA.
DR EMBL; AY010575; AAG32786.1; -; Genomic_DNA.
DR EMBL; AY010576; AAG32787.1; -; Genomic_DNA.
DR RefSeq; NP_523550.3; NM_078826.4.
DR AlphaFoldDB; O46227; -.
DR STRING; 7227.FBpp0079854; -.
DR PaxDb; O46227; -.
DR PRIDE; O46227; -.
DR EnsemblMetazoa; FBtr0080270; FBpp0079854; FBgn0267327.
DR GeneID; 3772154; -.
DR KEGG; dme:Dmel_CG6555; -.
DR UCSC; CG6555-RA; d. melanogaster.
DR CTD; 3772154; -.
DR FlyBase; FBgn0267327; Acp33A.
DR VEuPathDB; VectorBase:FBgn0267327; -.
DR HOGENOM; CLU_3175924_0_0_1; -.
DR OrthoDB; 1643347at2759; -.
DR PhylomeDB; O46227; -.
DR BioGRID-ORCS; 3772154; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3772154; -.
DR PRO; PR:O46227; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0267327; Expressed in male reproductive gland and 16 other tissues.
DR ExpressionAtlas; O46227; differential.
DR Genevisible; O46227; DM.
DR GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0005179; F:hormone activity; NAS:UniProtKB.
DR GO; GO:0045434; P:negative regulation of female receptivity, post-mating; NAS:UniProtKB.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
PE 2: Evidence at transcript level;
KW Behavior; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000305"
FT PEPTIDE 22..47
FT /note="Accessory gland peptide Acp33A"
FT /id="PRO_0000020582"
FT VARIANT 44..47
FT /note="PCCM -> RVACK (in strain: ZIM30C)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 47 AA; 5282 MW; 8AF0CCFA95797328 CRC64;
MLPSKRVPFL FTIILFLAGL GQHTTESVLP DCVLYPRCLI TKDPCCM
