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PANC_BRUME
ID   PANC_BRUME              Reviewed;         293 AA.
AC   Q8YFC9;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Pantothenate synthetase {ECO:0000255|HAMAP-Rule:MF_00158};
DE            Short=PS {ECO:0000255|HAMAP-Rule:MF_00158};
DE            EC=6.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00158};
DE   AltName: Full=Pantoate--beta-alanine ligase {ECO:0000255|HAMAP-Rule:MF_00158};
DE   AltName: Full=Pantoate-activating enzyme {ECO:0000255|HAMAP-Rule:MF_00158};
GN   Name=panC {ECO:0000255|HAMAP-Rule:MF_00158}; OrderedLocusNames=BMEI1593;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Catalyzes the condensation of pantoate with beta-alanine in
CC       an ATP-dependent reaction via a pantoyl-adenylate intermediate.
CC       {ECO:0000255|HAMAP-Rule:MF_00158}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP +
CC         diphosphate + H(+); Xref=Rhea:RHEA:10912, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:456215; EC=6.3.2.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00158};
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC       pantothenate from (R)-pantoate and beta-alanine: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00158}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00158}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00158}.
CC   -!- MISCELLANEOUS: The reaction proceeds by a bi uni uni bi ping pong
CC       mechanism. {ECO:0000255|HAMAP-Rule:MF_00158}.
CC   -!- SIMILARITY: Belongs to the pantothenate synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00158}.
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DR   EMBL; AE008917; AAL52774.1; -; Genomic_DNA.
DR   PIR; AC3451; AC3451.
DR   RefSeq; WP_004682909.1; NZ_GG703778.1.
DR   PDB; 3INN; X-ray; 2.10 A; A/B/C/D=1-293.
DR   PDBsum; 3INN; -.
DR   AlphaFoldDB; Q8YFC9; -.
DR   SMR; Q8YFC9; -.
DR   STRING; 224914.BMEI1593; -.
DR   EnsemblBacteria; AAL52774; AAL52774; BMEI1593.
DR   GeneID; 45123829; -.
DR   KEGG; bme:BMEI1593; -.
DR   PATRIC; fig|224914.52.peg.1997; -.
DR   eggNOG; COG0414; Bacteria.
DR   OMA; CNHKLEP; -.
DR   PhylomeDB; Q8YFC9; -.
DR   UniPathway; UPA00028; UER00005.
DR   EvolutionaryTrace; Q8YFC9; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004592; F:pantoate-beta-alanine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00560; PanC; 1.
DR   Gene3D; 3.30.1300.10; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00158; PanC; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR003721; Pantoate_ligase.
DR   InterPro; IPR042176; Pantoate_ligase_C.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR21299:SF1; PTHR21299:SF1; 1.
DR   Pfam; PF02569; Pantoate_ligase; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR   TIGRFAMs; TIGR00018; panC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cytoplasm; Ligase; Nucleotide-binding;
KW   Pantothenate biosynthesis.
FT   CHAIN           1..293
FT                   /note="Pantothenate synthetase"
FT                   /id="PRO_0000128210"
FT   ACT_SITE        37
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         30..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         61
FT                   /ligand="(R)-pantoate"
FT                   /ligand_id="ChEBI:CHEBI:15980"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         61
FT                   /ligand="beta-alanine"
FT                   /ligand_id="ChEBI:CHEBI:57966"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         147..150
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         153
FT                   /ligand="(R)-pantoate"
FT                   /ligand_id="ChEBI:CHEBI:15980"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         176
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   BINDING         184..187
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00158"
FT   STRAND          2..4
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           7..19
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          24..29
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           35..47
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          49..55
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           59..61
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   TURN            68..70
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           75..84
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          88..91
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           95..98
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          106..108
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           110..113
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           117..120
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           124..139
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          142..147
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           151..163
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          169..173
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           186..190
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           193..198
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           201..215
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   HELIX           220..230
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   TURN            231..233
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          237..245
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   TURN            247..249
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          261..269
FT                   /evidence="ECO:0007829|PDB:3INN"
FT   STRAND          272..280
FT                   /evidence="ECO:0007829|PDB:3INN"
SQ   SEQUENCE   293 AA;  32524 MW;  BF9F2C983D14E2D1 CRC64;
     MQIIHTIEEL RQALAPARQQ GKKIGFVPTM GYLHKGHLEL VRRARVENDV TLVSIFVNPL
     QFGANEDLGR YPRDLERDAG LLHDAQVDYL FAPTVSDMYP RPMQTVVDVP PLGNQMEGEA
     RPGHFAGVAT VVSKLFNIVG PDAAYFGEKD FQQLVIIRRM VDDMAIPVRI VGVETVREDD
     GLACSSRNVY LTPEQRRAAI IVPQALDEAD RLYRSGMDDP DALEAAIRTF IGRQPLAVPE
     VIAIRDPETL ERLPALQGRP ILVALFVRVG ATRLLDNRVI GHAAPQITQE RAA
 
 
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