ID   A34_VACCC               Reviewed;         168 AA.
AC   P21057;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 90.
DE   RecName: Full=Protein A34;
GN   ORFNames=A34R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Required for the envelopment of intracellular viral particles
CC       and egress of enveloped virions from the infected cell. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with proteins A36 AND B5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Present in the enveloped virion
CC       (EV) membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A34 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48161.1; -; Genomic_DNA.
DR   PIR; I42520; I42520.
DR   SMR; P21057; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..168
FT                   /note="Protein A34"
FT                   /id="PRO_0000099319"
FT   TOPO_DOM        1..14
FT                   /note="Intravirion"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..168
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          54..163
FT                   /note="C-type lectin"
FT   DISULFID        75..162
FT                   /evidence="ECO:0000250"
FT   DISULFID        141..154
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   168 AA;  19529 MW;  32CCB4B0614D2255 CRC64;
     MKSLNRQTVS MFKKLSVPAA IMMILSTIIS GIGTFLHYKE ELMPSACANG WIQYDKHCYL
     DTNIKMSTDN AVYQCRKLRA RLPRPDTRHL RVLFSIFYKD YWVSLKKTNN KWLDINNDKD
     IDISKLTNFK QLNSTTDAEA CYIYKSGKLV KTVCKSTQSV LCVKKFYK