ID   A34_VAR67               Reviewed;         168 AA.
AC   P33851;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein A34;
GN   ORFNames=A34R, A37R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Required for the envelopment of intracellular viral particles
CC       and egress of enveloped virions from the infected cell. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with proteins A36 AND B5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Present in the enveloped virion
CC       (EV) membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A34 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49082.1; -; Genomic_DNA.
DR   EMBL; X67115; CAA47508.1; -; Genomic_DNA.
DR   PIR; B36852; B36852.
DR   RefSeq; NP_042185.1; NC_001611.1.
DR   SMR; P33851; -.
DR   GeneID; 1486515; -.
DR   KEGG; vg:1486515; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..168
FT                   /note="Protein A34"
FT                   /id="PRO_0000099321"
FT   TOPO_DOM        1..14
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..168
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          54..163
FT                   /note="C-type lectin"
FT   DISULFID        75..162
FT                   /evidence="ECO:0000250"
FT   DISULFID        141..154
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   168 AA;  19612 MW;  28EA8FD95FA09634 CRC64;
     MKSLNRQTVS RFKKLSVPAA IMMILSTIIS GIGTFLHYKE ELMPSACANG WIQYDKHCYL
     DTNIKMSTDN TVYQCRKLRA RLPRPDTRHL RVLFSIFYKD YWVSLKKTNN KWLDINNDKD
     IDISKLTNFK QLNSTTDAEA CYIYKSGKLV KTVCKSTQSV LCVKRFYK