ID   A35_VACCC               Reviewed;         176 AA.
AC   P21058;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Protein A35;
DE   Flags: Precursor;
GN   ORFNames=A35R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Mildly affects the expression of MHC class II molecules on
CC       the surface of host antigen presenting cells (APCs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endosome {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A35 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48163.1; -; Genomic_DNA.
DR   PIR; A42521; A42521.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0039505; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II; IEA:UniProtKB-KW.
DR   InterPro; IPR009247; Chordopox_A35R.
DR   Pfam; PF05989; Chordopox_A35R; 1.
PE   2: Evidence at transcript level;
KW   Host endosome; Host-virus interaction;
KW   Inhibition of host adaptive immune response by virus;
KW   Inhibition of host MHC class II molecule presentation by virus;
KW   Reference proteome; Signal; Viral immunoevasion.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..176
FT                   /note="Protein A35"
FT                   /id="PRO_0000040597"
SQ   SEQUENCE   176 AA;  20005 MW;  D99E80B721171078 CRC64;
     MDAAFVITPM GVLTITDTLY DDLDISIMDF IGPYIIGNIK TVQIDVRDIK YSDMQKCYFS
     YKGKIVPQDS NDLARFNIYS ICAAYRSKNT IIIACDYDIM LDIEDKHQPF YLFPSIDVFN
     ATIIEAYNLY TAGDYHLIIN PSDNLKMKLS FNSSFCISDG NGWIIIDGKC NSNFLS