ID   PANE_ARATH              Reviewed;         365 AA.
AC   F4KIN4;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Putative 2-dehydropantoate 2-reductase;
DE            EC=1.1.1.169;
DE   AltName: Full=Ketopantoate reductase;
DE            Short=KPA reductase;
GN   Name=KPR; Synonyms=PANE; OrderedLocusNames=At5g34780; ORFNames=T3J11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate into
CC       pantoic acid. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.169;
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC       pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000305}.
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DR   EMBL; AC019012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED93907.1; -; Genomic_DNA.
DR   RefSeq; NP_198327.1; NM_122867.1.
DR   AlphaFoldDB; F4KIN4; -.
DR   SMR; F4KIN4; -.
DR   STRING; 3702.AT5G34780.1; -.
DR   PaxDb; F4KIN4; -.
DR   PRIDE; F4KIN4; -.
DR   EnsemblPlants; AT5G34780.1; AT5G34780.1; AT5G34780.
DR   GeneID; 833376; -.
DR   Gramene; AT5G34780.1; AT5G34780.1; AT5G34780.
DR   KEGG; ath:AT5G34780; -.
DR   Araport; AT5G34780; -.
DR   TAIR; locus:2184501; AT5G34780.
DR   eggNOG; KOG0048; Eukaryota.
DR   eggNOG; KOG1182; Eukaryota.
DR   HOGENOM; CLU_759423_0_0_1; -.
DR   InParanoid; F4KIN4; -.
DR   OrthoDB; 623111at2759; -.
DR   PhylomeDB; F4KIN4; -.
DR   UniPathway; UPA00028; UER00004.
DR   PRO; PR:F4KIN4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KIN4; baseline and differential.
DR   Genevisible; F4KIN4; AT.
DR   GO; GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; IBA:GO_Central.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; TAS:TAIR.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   GO; GO:0009083; P:branched-chain amino acid catabolic process; IBA:GO_Central.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; TAS:TAIR.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Pantothenate biosynthesis; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Putative 2-dehydropantoate 2-reductase"
FT                   /id="PRO_0000429570"
SQ   SEQUENCE   365 AA;  41601 MW;  8E330AB3A96229A5 CRC64;
     MESRCKKGYF RLAVIGLSKA KDCWEKNACA VTFIGDGGTS EGDFHAGLNF AAVMEAPVVF
     ICRNNGWAIS THISEQFRSD GIVVKGQAYG IRSIRVDGND ALAVYSAVCS AREMAVTEQR
     PVLIEMMIYR VGHHSTSDDS TKYRAADEIQ YWKMSRNSVN RFRKSVEDNG WWSEEDESKL
     RSNARKQLLQ AIQAAEKWEK QPLTELFNDV YDVKPKNLEE EELGLKELIE KQPQDYMMLK
     ELIPNWILGI GTLALRYDFQ ETLFNGWHAI AELQQLKLKI KLNSLLNDQA DTESLKAARN
     SALNVIQAMI IHLVLTLKGR FSLPLTEETV RFNEPIQLNQ NMVKDGGYTA ELFPIRKEEQ
     GEVRR