PANF_HAEIN
ID PANF_HAEIN Reviewed; 484 AA.
AC P44963;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Sodium/pantothenate symporter {ECO:0000250|UniProtKB:P16256};
DE AltName: Full=Pantothenate permease {ECO:0000250|UniProtKB:P16256};
GN Name=panF; OrderedLocusNames=HI_0975;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Catalyzes the sodium-dependent uptake of extracellular
CC pantothenate. {ECO:0000250|UniProtKB:P16256}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) +
CC Na(+)(out); Xref=Rhea:RHEA:29927, ChEBI:CHEBI:29032,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000250|UniProtKB:P16256};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29929;
CC Evidence={ECO:0000250|UniProtKB:P16256};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P16256}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; L42023; AAC22634.1; -; Genomic_DNA.
DR PIR; H64105; H64105.
DR RefSeq; NP_439137.1; NC_000907.1.
DR RefSeq; WP_005647973.1; NC_000907.1.
DR AlphaFoldDB; P44963; -.
DR SMR; P44963; -.
DR STRING; 71421.HI_0975; -.
DR EnsemblBacteria; AAC22634; AAC22634; HI_0975.
DR KEGG; hin:HI_0975; -.
DR PATRIC; fig|71421.8.peg.1017; -.
DR eggNOG; COG4145; Bacteria.
DR HOGENOM; CLU_018808_15_1_6; -.
DR OMA; GWWGMRR; -.
DR PhylomeDB; P44963; -.
DR BioCyc; HINF71421:G1GJ1-1017-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015233; F:pantothenate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015887; P:pantothenate transmembrane transport; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR CDD; cd10327; SLC5sbd_PanF; 1.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR011849; Na/pantothenate_symporter.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR02119; panF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..484
FT /note="Sodium/pantothenate symporter"
FT /id="PRO_0000105403"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 484 AA; 52501 MW; BE6EFB27C1DE9C06 CRC64;
MNLGIILPLI IYLTFVFGAA IFAYVKRTKG DFLTEYYVGN RSMTGFVLAM TTASTYASAS
SFVGGPGAAY KYGLGWVLLA MIQVPVVWLA LGALGKKFAL LSRETNALTI NDLFFYRYKN
KYLVWLSSLA LLLAFFAAMT VQFIGGARLL ETTIGISYTQ ALLLFALTVG IYTFIGGFRA
VVLTDTIQGT VMIFGTIILL IGTIYALGGV ESAVNKLTEI DPDLVTPYGP NGMLDFQFMA
SFWILVCFGV VGLPHTAVRC MAFKDSKALH RGMLIGTIVL SIIMLGMHLA GALGRAVIPN
LTVSDQVIPT LMIKVLPPIV AGIFLAAPMS AIMSTIDAQL IQSSSIFVKD LYLSAKPEAA
KNEKKVSYFS SIITLILTAL LIFAALNPPD MIIWLNLFAF GGLEAAFLWV IVLGIYWDKA
NAYGALSSMI IGLGSYILLT QLGIKLFNFH QIVPSLVFGL IAFLVGNKLG ERRIEKTQLK
VTAL
