ID   PANK1_ORYSJ             Reviewed;         666 AA.
AC   Q69TF4; A0A0P0WUF1;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pantothenate kinase 1;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase 1;
GN   OrderedLocusNames=Os06g0207000, LOC_Os06g09910; ORFNames=P0529B09.16;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Catalyzes the phosphorylation of pantothenate the first step
CC       in CoA biosynthesis. May play a role in the physiological regulation of
CC       the intracellular CoA concentration (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP +
CC         H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC         EC=2.7.1.33;
CC   -!- ACTIVITY REGULATION: Regulated by feedback inhibition by malonyl-CoA.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 1/5.
CC   -!- SIMILARITY: Belongs to the type II pantothenate kinase family.
CC       {ECO:0000305}.
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DR   EMBL; AP004754; BAD35853.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAF19012.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS96706.1; -; Genomic_DNA.
DR   EMBL; AK067115; BAG90276.1; -; mRNA.
DR   RefSeq; XP_015644088.1; XM_015788602.1.
DR   AlphaFoldDB; Q69TF4; -.
DR   SMR; Q69TF4; -.
DR   STRING; 4530.OS06T0207000-01; -.
DR   PaxDb; Q69TF4; -.
DR   PRIDE; Q69TF4; -.
DR   EnsemblPlants; Os06t0207000-01; Os06t0207000-01; Os06g0207000.
DR   GeneID; 4340439; -.
DR   Gramene; Os06t0207000-01; Os06t0207000-01; Os06g0207000.
DR   KEGG; osa:4340439; -.
DR   eggNOG; KOG2201; Eukaryota.
DR   HOGENOM; CLU_035665_0_0_1; -.
DR   InParanoid; Q69TF4; -.
DR   OMA; EDTTFEG; -.
DR   OrthoDB; 865329at2759; -.
DR   PlantReactome; R-OSA-1119394; Pantothenate and coenzyme A biosynthesis III.
DR   UniPathway; UPA00241; UER00352.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q69TF4; OS.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004594; F:pantothenate kinase activity; IBA:GO_Central.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR004567; Type_II_PanK.
DR   PANTHER; PTHR12280; PTHR12280; 3.
DR   Pfam; PF03630; Fumble; 2.
DR   SUPFAM; SSF53067; SSF53067; 3.
DR   TIGRFAMs; TIGR00555; panK_eukar; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coenzyme A biosynthesis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..666
FT                   /note="Pantothenate kinase 1"
FT                   /id="PRO_0000429406"
SQ   SEQUENCE   666 AA;  72299 MW;  81FFC0B2A4CA07EF CRC64;
     MGGLRVDLSG AEIRVDPACG AAADDGGSPP VFLPRQPAAP PLLALDIGGT LIKLVYTASC
     GGGGAELRFA KFERRRMQEC FDFVRAQGLV HRNGSTMGSS KENIALKASG GGAYKYTEDF
     REKLGVCLDK VDEMDSVVSG ANFLLQSVPG AAFTHMNGKK SSVDISPNNL FPYLLVNIGS
     GVSILKVTGN RKFERVTGTH IGGGTMFGLA KLLTGCKSYD EFLQLSQKGD NFVLDLIVKD
     ICGELVCQKQ GLSTSTLASS FGKVITSKKK LTDYRPEDLA STLLSAFTYN IAQISFLVAS
     ILHLRRVFFG GSYIRGHKST MQNISYAIDF WSQSKMQAVF LQHEGYLGAL GALMSYGDSG
     DKNMNLEEMK EEENIHESAT PIDETSTDEH NDGNIFPYLL VNIGSGVSMI EVTGNGKFER
     IIGSHLGGGT ILGLARLLTG CSSYDEFLEL SQRGNNLAVD LTVGDIYGEH GYPKIGLPAS
     TTAASFGKVS SSRLSEYKVE DLAAALLNSF TYNIGQIAYF VANLSGLKRI FFRGAYICGH
     EKTMDKISHS LKYWSKGQVQ TTFLCHEGFL GTLGAFWSYE NMGIDGLAAH EVIREVLLGA
     PYTGQLPSLP LTHQQDNGED TTIEGEVERL RHDNAVLKAE LERLQRENTE LKAKLVKSGK
     PNTFYH