ID   PANO1_HUMAN             Reviewed;         215 AA.
AC   I0J062;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Proapoptotic nucleolar protein 1 {ECO:0000303|PubMed:22094112, ECO:0000312|HGNC:HGNC:51237};
GN   Name=PANO1 {ECO:0000312|HGNC:HGNC:51237};
GN   Synonyms=PANO {ECO:0000303|PubMed:22094112};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RX   PubMed=22094112; DOI=10.1016/j.yexcr.2011.10.019;
RA   Watari A., Li Y., Higashiyama S., Yutsudo M.;
RT   "A novel proapoptotic gene PANO encodes a post-translational modulator of
RT   the tumor suppressor p14ARF.";
RL   Exp. Cell Res. 318:187-195(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: Apoptosis-inducing protein that modulates the tumor
CC       suppressor function of CDKN2A/p14ARF. Enhances the stability of
CC       CDKN2A/p14ARF protein by protecting it from degradation. May act as a
CC       tumor suppressor (PubMed:22094112). {ECO:0000269|PubMed:22094112}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:22094112}.
CC       Note=Colocalizes with CDKN2A/p14ARF in the nucleolus.
CC       {ECO:0000269|PubMed:22094112}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:22094112}.
CC   -!- INDUCTION: Up-regulated after serum withdrawal.
CC       {ECO:0000269|PubMed:22094112}.
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DR   EMBL; AB430851; BAM10911.1; -; mRNA.
DR   EMBL; AP006621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001280096.1; NM_001293167.1.
DR   AlphaFoldDB; I0J062; -.
DR   STRING; 9606.ENSP00000479258; -.
DR   BioMuta; PANO1; -.
DR   PRIDE; I0J062; -.
DR   DNASU; 101927423; -.
DR   GeneID; 101927423; -.
DR   UCSC; uc057xnb.1; human.
DR   CTD; 101927423; -.
DR   GeneCards; PANO1; -.
DR   HGNC; HGNC:51237; PANO1.
DR   HPA; ENSG00000288675; Tissue enhanced (brain, pancreas).
DR   neXtProt; NX_I0J062; -.
DR   VEuPathDB; HostDB:ENSG00000288675; -.
DR   GeneTree; ENSGT00910000147257; -.
DR   HOGENOM; CLU_1282854_0_0_1; -.
DR   OMA; PRTCPQM; -.
DR   OrthoDB; 1401828at2759; -.
DR   PathwayCommons; I0J062; -.
DR   BioGRID-ORCS; 101927423; 3 hits in 76 CRISPR screens.
DR   GenomeRNAi; 101927423; -.
DR   Pharos; I0J062; Tdark.
DR   PRO; PR:I0J062; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; I0J062; protein.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR   GO; GO:0031647; P:regulation of protein stability; IDA:UniProtKB.
PE   2: Evidence at transcript level;
KW   Apoptosis; Nucleus; Reference proteome; Tumor suppressor.
FT   CHAIN           1..215
FT                   /note="Proapoptotic nucleolar protein 1"
FT                   /id="PRO_0000431904"
FT   REGION          35..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..215
FT                   /note="Necessary for nucleolar localization"
FT                   /evidence="ECO:0000269|PubMed:22094112"
SQ   SEQUENCE   215 AA;  22842 MW;  E8D35E5DFC41177D CRC64;
     MGVRLRVWPA APHSISRCPR PLGAVLSILL AGGSRKGTPT ARCLGQRTKE KRVGGRSLRS
     EAGSGPCPTA GAQPTAPSSA WPPRLRPRTC PQMSGELPRV RPTRVGLSSL GSGPGHPPSG
     TRMCGERARN RRGRARRLTP EQPRIGASAG PGPPLPPARP RCSGSCHLPR PPQHLSPPQP
     GRVRMGAAEG SRRADTHHAR RRRRARLPAP RSAST