ID   PANS2_ARATH             Reviewed;         194 AA.
AC   Q94CK6;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein PATRONUS 2 {ECO:0000303|PubMed:24206843};
GN   Name=PANS2 {ECO:0000303|PubMed:24206843};
GN   OrderedLocusNames=At5g12360 {ECO:0000312|Araport:AT5G12360};
GN   ORFNames=T2L20 {ECO:0000312|EMBL:CAC42897.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=24728280; DOI=10.1371/journal.pone.0094077;
RA   Vukasinovic N., Cvrckova F., Elias M., Cole R., Fowler J.E., Zarsky V.,
RA   Synek L.;
RT   "Dissecting a hidden gene duplication: the Arabidopsis thaliana SEC10
RT   locus.";
RL   PLoS ONE 9:E94077-E94077(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=16244158; DOI=10.1104/pp.105.063479;
RA   Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA   Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT   "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT   reveals numerous transcript variants.";
RL   Plant Physiol. 139:1323-1337(2005).
RN   [5]
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=24206843; DOI=10.1016/j.cub.2013.08.036;
RA   Cromer L., Jolivet S., Horlow C., Chelysheva L., Heyman J., De Jaeger G.,
RA   Koncz C., De Veylder L., Mercier R.;
RT   "Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at
RT   anaphase I and by PATRONUS at interkinesis.";
RL   Curr. Biol. 23:2090-2099(2013).
RN   [6]
RP   INDUCTION.
RX   PubMed=26261921; DOI=10.1111/nph.13589;
RA   Juraniec M., Heyman J., Schubert V., Salis P., De Veylder L.,
RA   Verbruggen N.;
RT   "Arabidopsis COPPER MODIFIED RESISTANCE1/PATRONUS1 is essential for growth
RT   adaptation to stress and required for mitotic onset control.";
RL   New Phytol. 209:177-191(2016).
CC   -!- FUNCTION: Not required for protection of centromeric cohesion.
CC       {ECO:0000269|PubMed:24206843}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. {ECO:0000305};
CC       Name=1;
CC         IsoId=Q94CK6-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Expressed in somatic and reproductive tissues.
CC       {ECO:0000269|PubMed:24206843}.
CC   -!- INDUCTION: Constitutive expression with no clear cell-cycle regulation.
CC       {ECO:0000269|PubMed:26261921}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype and no meiotic or pollen
CC       development defects. Pans1 and pans2 double mutants are lethal when
CC       homozygous. {ECO:0000269|PubMed:24206843}.
CC   -!- MISCELLANEOUS: Patronus is Latin for protector.
CC       {ECO:0000305|PubMed:24206843}.
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DR   EMBL; HG764169; CDJ79773.1; -; Genomic_DNA.
DR   EMBL; AL592312; CAC42897.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91799.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM68519.1; -; Genomic_DNA.
DR   EMBL; AY735679; AAU44549.1; -; mRNA.
DR   RefSeq; NP_001318549.1; NM_001343236.1. [Q94CK6-1]
DR   RefSeq; NP_568269.1; NM_121274.4. [Q94CK6-1]
DR   AlphaFoldDB; Q94CK6; -.
DR   STRING; 3702.AT5G12360.1; -.
DR   PaxDb; Q94CK6; -.
DR   PRIDE; Q94CK6; -.
DR   ProteomicsDB; 236269; -. [Q94CK6-1]
DR   EnsemblPlants; AT5G12360.1; AT5G12360.1; AT5G12360. [Q94CK6-1]
DR   EnsemblPlants; AT5G12360.2; AT5G12360.2; AT5G12360. [Q94CK6-1]
DR   GeneID; 831111; -.
DR   Gramene; AT5G12360.1; AT5G12360.1; AT5G12360. [Q94CK6-1]
DR   Gramene; AT5G12360.2; AT5G12360.2; AT5G12360. [Q94CK6-1]
DR   KEGG; ath:AT5G12360; -.
DR   Araport; AT5G12360; -.
DR   TAIR; locus:505006604; AT5G12360.
DR   eggNOG; ENOG502S5FX; Eukaryota.
DR   HOGENOM; CLU_1423353_0_0_1; -.
DR   InParanoid; Q94CK6; -.
DR   OMA; QQNQWDS; -.
DR   OrthoDB; 1331402at2759; -.
DR   PhylomeDB; Q94CK6; -.
DR   PRO; PR:Q94CK6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q94CK6; baseline and differential.
DR   GO; GO:0034090; P:maintenance of meiotic sister chromatid cohesion; IMP:TAIR.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:InterPro.
DR   InterPro; IPR039326; Patronus.
DR   PANTHER; PTHR35125; PTHR35125; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Protein PATRONUS 2"
FT                   /id="PRO_0000438545"
FT   REGION          28..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           14..16
FT                   /note="DEN-box"
FT                   /evidence="ECO:0000305"
FT   MOTIF           48..50
FT                   /note="D-box"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   194 AA;  21799 MW;  26C2C9D5CC2415B6 CRC64;
     MANTILRGQM IFQDENALAA LGKKAVAAGK GKSSLAAPKK NGAGFGSRKA LHDITNKSKL
     QPQASSTTRK DVEGVDFDIA KEGFLHDHSK CIEEQQQDQW DSYFSEHIIL HGHETNIKEG
     VPQYNNIQEI DAENSWDELK EIPMEEFSDL LECSTQWRSP PDSLSHHHSS LPSSPLPWHF
     ETVEFKLKED EDTT